|Citation||Xia, Y., Karin, M. (2004). The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 14(2): 94--101. (Export to RIS)|
|PubMed Abstract||Originally identified as stress-activated protein kinases that control cell survival and proliferation through transcription factor c-Jun, the Jun N-terminal kinase (JNK) subgroup of MAP kinases (MAPKs) have recently emerged as crucial regulators of cell migration and the morphogenetic movement of epithelial sheets. In Drosophila, a well-orchestrated JNK signaling pathway controls formation of actin stress fibers and cell shape changes, which are required for the sealing of embryonic epidermis in a process known as dorsal closure. The JNK pathway is also involved in morphogenetic processes in mice including closure of the eyelid, neural tube and optic fissure. This article focuses on recent advances in understanding the role of JNK pathway in the regulation of cell migration, cytoskeleton rearrangement and the morphogenesis of epithelial sheets.|
What does this section display?
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Language of Publication||English|
|Additional Languages of Abstract|
|Also Published As|
|Abbreviation||Trends Cell Biol.|
|Title||Trends in Cell Biology|
|Data from Reference|