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Gilfillan, G.D., Dahlsveen, I.K., Becker, P.B. (2004). Lifting a chromosome: dosage compensation in Drosophila melanogaster.  FEBS Lett. 567(1): 8--14.
FlyBase ID
FBrf0179012
Publication Type
Review
Abstract
Twofold differences in gene expression levels can be vital for an organism. This is beautifully illustrated by the process of 'dosage compensation' in Drosophila, which doubles transcription from the single male X chromosome to equal the mRNA levels originating from the two X chromosomes in female cells. Failure of the process leads to male-specific lethality. A number of recent publications have furthered our understanding of the ribonucleoprotein complex, which mediates dosage compensation and how it targets the male X chromosome. Deciphering the principles of X chromosome recognition and the nature of the chromatin configuration, that allows fine-tuning of transcription, remain the most interesting challenges.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FEBS Lett.
    Title
    FEBS Letters
    Publication Year
    1968-
    ISBN/ISSN
    0014-5793
    Data From Reference