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Citation
Leclerc, V., Reichhart, J.M. (2004). The immune response of Drosophila melanogaster.  Immunol. Rev. 198(): 59--71.
FlyBase ID
FBrf0179043
Publication Type
Review
Abstract

The response of the fruit fly Drosophila melanogaster to various microorganism infections relies on a multilayered defense. The epithelia constitute a first and efficient barrier. Innate immunity is activated when microorganisms succeed in entering the body cavity of the fly. Invading microorganisms are killed by the combined action of cellular and humoral processes. They are phagocytosed by specialized blood cells, surrounded by toxic melanin, or lysed by antibacterial peptides secreted into the hemolymph by fat body cells. During the last few years, research has focused on the mechanisms of microbial recognition by various pattern recognition receptors and of the subsequent induction of antimicrobial peptide expression. The cellular arm of the Drosophila innate immune system, which was somehow neglected, now constitutes the new frontier.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Compendium
    Abbreviation
    Immunol. Rev.
    Title
    Immunological Reviews
    Publication Year
    1977-
    ISBN/ISSN
    0150-2896
    Data From Reference