Reference Report

Reference
Citation	Adolfsen, B., Saraswati, S., Yoshihara, M., Littleton, J.T. (2004). Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. J. Cell Biol. 166(2): 249--260. (Export to RIS)
FlyBase ID	FBrf0179104
Publication Type	Research paper
PubMed ID	15263020
PubMed Abstract	The synaptotagmin family has been implicated in calcium-dependent neurotransmitter release, although Synaptotagmin 1 is the only isoform demonstrated to control synaptic vesicle fusion. Here, we report the characterization of the six remaining synaptotagmin isoforms encoded in the Drosophila genome, including homologues of mammalian Synaptotagmins 4, 7, 12, and 14. Like Synaptotagmin 1, Synaptotagmin 4 is ubiquitously present at synapses, but localizes to the postsynaptic compartment. The remaining isoforms were not found at synapses (Synaptotagmin 7), expressed at very low levels (Synaptotagmins 12 and 14), or in subsets of putative neurosecretory cells (Synaptotagmins alpha and beta). Consistent with their distinct localizations, overexpression of Synaptotagmin 4 or 7 cannot functionally substitute for the loss of Synaptotagmin 1 in synaptic transmission. Our results indicate that synaptotagmins are differentially distributed to unique subcellular compartments. In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Cell Biol.
Title	Journal of Cell Biology
Publication Year	1966-
ISBN/ISSN	0021-9525
Data from Reference
Alleles (8)
	Scer\GAL4^elav.PLu Scer\GAL4^elav-C155 Syt1^AD4 Syt1^N13 Syt1^Scer\UAS.cLa Syt4^BA1 Syt4^Scer\UAS.cLa Syt7^Scer\UAS.cAa
Constructs (3)
	P{UAS-Syt7.A} P{UAS-sytI.L} P{UAS-SytIV.L}
Genes (25)
	Aats-his Act88F bcd comt dpp Fas2 GluRIIA Granulophilin N Nrx-1 n-syb Otoferlin Rop Scer\GAL4 Syn synaptogyrin Syt1 Syt4 Syt7 Syt12 Syt14 Sytα Sytβ Syx1A twi
Insertions (1)
	P{EPgy2}EY09259
Natural transposons (1)
	P-element