Reference Report

Reference
Citation	Chao, J.L., Tsai, Y.C., Chiu, S.J., Sun, Y.H. (2004). Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye. Development 131(16): 3839--3847. (Export to RIS)
FlyBase ID	FBrf0179159
Publication Type	Research paper
PubMed ID	15253935
PubMed Abstract	Notch (N) signal is activated at the dorsoventral (DV) border of the Drosophila eye disc and is important for growth of the eye disc. In this study, we showed that the Pax protein Eyg is a major effector mediating the growth promotion function of N. eyg transcription is induced by N signaling occurring at the DV border. Like N, eyg controls growth of the eye disc. Loss of N signaling can be compensated by overexpressing eyg, whereas loss of the downstream eyg blocked the function of N signaling. In addition, we showed that N and eyg could induce expression of upd, which encodes the ligand for the Jak/STAT pathway and acts over long distance to promote cell proliferation. Loss of eyg or N can be compensated by overexpressing upd. These results suggest that upd is a major effector mediating the function of eyg and N. The functional link from N to eyg to upd explains how the localized Notch activation can achieve global growth control.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (21)
	Avic\GFP^{S65T.Scer\UAS} Dl^RevF10 Dl^Scer\UAS.cHa Ecol\lacZ^os-PD eyg¹ eyg^M3-12 eyg^{Scer\UAS.lune} H^E31 H^Scer\UAS.cGa N^{ECN.Scer\UAS.cGa} N^ICN.Scer\UAS os¹ os^Scer\UAS.cZa Scer\GAL4^Act5C.PI Scer\GAL4^dpp.blk1 Scer\GAL4^ey.PH Scer\GAL4^eyg.E2-EX Scer\GAL4^{Scer\FRT.Act5C} Ser^RX82 Ser^Scer\UAS.cSa Su(H)^Scer\UAS.cNa
Constructs (14)
	P{Act5C-GAL4} P{AyGAL4} P{eyg.E2.Ex-Gal4} P{GAL4-dpp.blk1} P{GAL4-ey.H} P{UAS-Dl.H} P{UAS-eyg.lune} P{UAS-GFP.S65T} P{UAS-H.G} P{UAS-N.ECN.G} P{UAS-N.ICN} P{UAS-os.Z} P{UAS-Ser.mg5603} P{UAS-Su(H).N}
Genes (13)
	Avic\GFP dac Dl Ecol\lacZ elav eyg H N os Scer\GAL4 Ser Su(H) wg
Insertions (1)
	P{lacW}PD