Reference Report

Reference
Citation	Finelli, A., Kelkar, A., Song, H.J., Yang, H., Konsolaki, M. (2004). A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol. Cell. Neurosci. 26(3): 365--375. (Export to RIS)
FlyBase ID	FBrf0179205
Publication Type	Research paper
PubMed ID	15234342
PubMed Abstract	Alzheimer's disease is a neurological disorder resulting in the degeneration and death of brain neurons controlling memory, cognition and behavior. Although overproduction of Abeta peptides is widely considered a causative event in the disease, the mechanisms by which Abeta peptides cause neurodegeneration and the processes of Abeta clearance and degradation remain unclear. To address these issues, we have expressed the Abeta peptides in Drosophila melanogaster. We show that overexpression of Abeta42 peptides in the nervous system results in phenotypes associated with neuronal degeneration in a dose- and age-dependent manner. We further show that a mutation in a Drosophila neprilysin gene suppresses the Abeta42 phenotypes by lowering the levels of the Abeta42 peptide, supporting the role of neprilysin in the catabolism of Abeta peptides in vivo. We propose that our Drosophila model is suitable for the study and elucidation of Abeta metabolism and toxicity at the genetic level.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Neurosci.
Title	Molecular and Cellular Neurosciences
Publication Year	1990-
ISBN/ISSN	1044-7431
Data from Reference
Alleles (10)
	Hsap\APP^Aβ40.GMR Hsap\APP^{Aβ40.Scer\UAS} Hsap\APP^Aβ42.GMR Hsap\APP^{Aβ42.Scer\UAS} Hsap\APP^C99.Scer\UAS Ide^EP3099 Nep2^EP3549 Scer\GAL4^elav-C155 Scer\GAL4^ey.PU Scer\GAL4^tub.PU
Constructs (7)
	P{ey-GAL4.U} P{GMR-APP.Aβ40} P{GMR-APP.Aβ42} P{tub-GAL4.U} P{UAS-APP.Aβ40} P{UAS-APP.Aβ42} P{UAS-APP.C99}
Genes (4)
	Hsap\APP Ide Nep2 Scer\GAL4
Insertions (11)
	P{EP}Nep2^EP3549 P{EP}RhoBTB^EP3099 P{GawB}elav^C155 P{GMR-APP.Aβ40}L1 P{GMR-APP.Aβ42}K1 P{GMR-APP.Aβ42}K3 P{GMR-APP.Aβ42}K10 P{GMR-APP.Aβ42}K52 P{GMR-APP.Aβ42}K53 P{UAS-APP.Aβ42}H29.3 P{UAS-APP.C99}I8
Natural transposons (1)
	P-element