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Citation
Gallio, M., Englund, C., Kylsten, P., Samakovlis, C. (2004). Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline.  Development 131(15): 3605--3614.
FlyBase ID
FBrf0179216
Publication Type
Research paper
Abstract

EGF-receptor ligands act as chemoattractants for migrating epithelial cells during organogenesis and wound healing. We present evidence that Rhomboid 3/EGF signalling, which originates from the midline of the Drosophila ventral nerve cord, repels tracheal ganglionic branches and prevents them from crossing it. rho3 acts independently from the main midline repellent Slit, and originates from a different sub-population of midline cells: the VUM neurons. Expression of dominant-negative Egfr or Ras induces midline crosses, whereas activation of the Egfr or Ras in the leading cell of the ganglionic branch can induce premature turns away from the midline. This suggests that the level of Egfr intracellular signalling, rather than the asymmetric activation of the receptor on the cell surface, is an important determinant in ganglionic branch repulsion. We propose that Egfr activation provides a necessary switch for the interpretation of a yet unknown repellent function of the midline.

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Note

Attraction or repulsion: a matter of individual taste?
Wells and Lillien, 2004, Sci. STKE 2004(253): pe47 [FBrf0180673]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference