Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Kapahi, P., Zid, B.M., Harper, T., Koslover, D., Sapin, V., Benzer, S. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14(10): 885--890. (Export to RIS) | ||
| FlyBase ID | FBrf0179269 | ||
| Publication Type | Research paper | ||
| PubMed ID | 15186745 | ||
| PubMed Abstract | In many species, reducing nutrient intake without causing malnutrition extends lifespan. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known to alter nutrient sensing, has been shown to extend lifespan in various species. In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we examined the role of TOR pathway genes in regulating lifespan by using Drosophila. We show that inhibition of TOR signaling pathway by alteration of the expression of genes in this nutrient-sensing pathway, which is conserved from yeast to human, extends lifespan in a manner that may overlap with known effects of dietary restriction on longevity. In Drosophila, TSC1 and TSC2 (tuberous sclerosis complex genes 1 and 2) act together to inhibit TOR (target of rapamycin), which mediates a signaling pathway that couples amino acid availability to S6 kinase, translation initiation, and growth. We find that overexpression of dTsc1, dTsc2, or dominant-negative forms of dTOR or dS6K all cause lifespan extension. Modulation of expression in the fat is sufficient for the lifespan-extension effects. The lifespan extensions are dependent on nutritional condition, suggesting a possible link between the TOR pathway and dietary restriction. | ||
| DOI | |||
| Related Publication(s) | |||
| Erratum | Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Kapahi et al., 2004, Curr. Biol. 14: 1789 [FBrf0185644] |
||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Curr. Biol. | ||
| Title | Current Biology | ||
| Publication Year | 1991- | ||
| ISBN/ISSN | 0960-9822 | ||
|
Data from Reference
|
|||
| Alleles (14)
|
|||
| Constructs (9)
|
|||
| Genes (8)
|
|||
| Insertions (5)
|
|||
| Transcripts (3)
|
|||