Reference Report

Reference
Citation	Landis, G.N., Abdueva, D., Skvortsov, D., Yang, J., Rabin, B.E., Carrick, J., Tavare, S., Tower, J. (2004). Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 101(20): 7663--7668. (Export to RIS)
FlyBase ID	FBrf0179295
Publication Type	Research paper
PubMed ID	15136717
PubMed Abstract	Affymetrix GeneChips were used to measure RNA abundance for approximately 13,500 Drosophila genes in young, old, and 100% oxygen-stressed flies. Data were analyzed by using a recently developed background correction algorithm and a robust multichip model-based statistical analysis that dramatically increased the ability to identify changes in gene expression. Aging and oxidative stress responses shared the up-regulation of purine biosynthesis, heat shock protein, antioxidant, and innate immune response genes. Results were confirmed by using Northerns and transgenic reporters. Immune response gene promoters linked to GFP allowed longitudinal assay of gene expression during aging in individual flies. Immune reporter expression in young flies was partially predictive of remaining life span, suggesting their potential as biomonitors of aging.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (5)
	Avic\GFP^{EGFP.Dro.JM876} Avic\GFP^EGFP.Mtk Avic\GFP^S65T.Drs Ecol\lacZ^{Hsp22.5'Δ-314} Ecol\lacZ^{Hsp70Bb.-194.+276}
Constructs (5)
	P{Dro-GFP.JM876} P{Drs-GFP.JM802} P{Hsp22-lacZ.5'Δ-314} P{Hsp70Bb-lacZ.-194.+276} P{Mtk-GFP.JM879}
Genes (22)
	ade3 Aph-4 AttA Avic\GFP Cct1 Def DnaJ-1 Dpt Dro Drs Ecol\lacZ GstD2 Hsp22 Hsp70Aa Hsp70Ab Hsp70Ba Hsp70Bb Hsp70Bbb Hsp70Bc l(2)efl Nmdmc RpA-70