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Citation
Landis, G.N., Abdueva, D., Skvortsov, D., Yang, J., Rabin, B.E., Carrick, J., Tavare, S., Tower, J. (2004). Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster.  Proc. Natl. Acad. Sci. U.S.A. 101(20): 7663--7668.
FlyBase ID
FBrf0179295
Publication Type
Research paper
Abstract

Affymetrix GeneChips were used to measure RNA abundance for approximately 13,500 Drosophila genes in young, old, and 100% oxygen-stressed flies. Data were analyzed by using a recently developed background correction algorithm and a robust multichip model-based statistical analysis that dramatically increased the ability to identify changes in gene expression. Aging and oxidative stress responses shared the up-regulation of purine biosynthesis, heat shock protein, antioxidant, and innate immune response genes. Results were confirmed by using Northerns and transgenic reporters. Immune response gene promoters linked to GFP allowed longitudinal assay of gene expression during aging in individual flies. Immune reporter expression in young flies was partially predictive of remaining life span, suggesting their potential as biomonitors of aging.

PubMed ID
PubMed Central ID
PMC419663 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference