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Citation
Mershin, A., Pavlopoulos, E., Fitch, O., Braden, B.C., Nanopoulos, D.V., Skoulakis, E.M. (2004). Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons.  Learn. Mem. 11(3): 277--287.
FlyBase ID
FBrf0179337
Publication Type
Research paper
Abstract

Mutations in the neuronal-specific microtubule-binding protein TAU are associated with several dementias and neurodegenerative diseases. However, the effects of elevated TAU accumulation on behavioral plasticity are unknown. We report that directed expression of wild-type vertebrate and Drosophila TAU in adult mushroom body neurons, centers for olfactory learning and memory in Drosophila, strongly compromised associative olfactory learning and memory, but olfactory conditioning-relevant osmotactic and mechanosensory responses remained intact. In addition, TAU accumulation in mushroom body neurons did not result in detectable neurodegeneration or premature death. Therefore, TAU-mediated structural or functional perturbation of the microtubular cytoskeleton in mushroom body neurons is likely causal of the behavioral deficit. These results indicate that behavioral plasticity decrements may be the earliest detectable manifestations of tauopathies.

PubMed ID
PubMed Central ID
PMC419730 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Learn. Mem.
    Title
    Learning and Memory
    Publication Year
    1994-
    ISBN/ISSN
    1072-0502
    Data From Reference
    Alleles (7)
    Genes (7)
    Human Disease Models (1)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (5)