Reference Report

Reference
Citation	Milan, M., Pham, T.T., Cohen, S.M. (2004). Osa modulates the expression of Apterous target genes in the Drosophila wing. Mech. Dev. 121(5): 491--497. (Export to RIS)
FlyBase ID	FBrf0179340
Publication Type	Research paper
PubMed ID	15147766
PubMed Abstract	The establishment of the dorsal-ventral axis of the Drosophila wing depends on the activity of the LIM-homeodomain protein Apterous. Apterous activity depends on the formation of a higher order complex with its cofactor Chip to induce the expression of its target genes. Apterous activity levels are modulated during development by dLMO. Expression of dLMO in the Drosophila wing is regulated by two distinct Chip dependent mechanisms. Early in development, Chip bridges two molecules of Apterous to induce expression of dLMO in the dorsal compartment. Later in development, Chip, independently of Apterous, is required for expression of dLMO in the wing pouch. We have conducted a modular P-element based EP (enhancer/promoter) misexpression screen to look for genes involved in Apterous activity. We have found Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing. Osa mediates activation of some Apterous target genes and repression of others, including dLMO. Osa has been shown to bind Chip. We propose that Chip recruits Osa to the Apterous target genes, thus mediating activation or repression of their expression.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (25)
	ap^md544 ap^Scer\UAS.cMa ap^UGO35 Avic\GFP^Scer\UAS.cUa brm^T362 Bx¹ Bx^hdpR590 Bx^MS1096 Chi^unspecified Ecol\lacZ^fng-rG554 fng⁸⁰ fng^Scer\UAS.cKa osa³⁰⁸ osa^EP3-473 osa^EP3-619 osa^EP3-900 osa^EP3-941 osa^EP3-1074 osa^EP3-1386 osa^EP3-1591 osa^Scer\UAS.cCa Scer\GAL4^ap-md544 Scer\GAL4^ptc-559.1 Ser^RX82 Ser^Scer\UAS.cSa
Constructs (5)
	P{UAS-ap.M} P{UAS-fng.K} P{UAS-GFP.U} P{UAS-osa} P{UAS-Ser.mg5603}
Genes (12)
	ap Avic\GFP brm Bx Chi Dl Ecol\lacZ fng osa Scer\GAL4 Ser wg
Insertions (10)
	P{EP}osa^EP3-473 P{EP}osa^EP3-619 P{EP}osa^EP3-900 P{EP}osa^EP3-941 P{EP}osa^EP3-1074 P{EP}osa^EP3-1386 P{EP}osa^EP3-1591 P{GawB}ap^md544 P{GawB}ptc^559.1 P{PZ}fng^rG554