Reference Report

Reference
Citation	Rusconi, J.C., Fink, J.L., Cagan, R. (2004). klumpfuss regulates cell death in the Drosophila retina. Mech. Dev. 121(6): 537--546. (Export to RIS)
FlyBase ID	FBrf0179423
Publication Type	Research paper
PubMed ID	15172685
PubMed Abstract	Programmed cell death (PCD) plays a central role in the sculpting and maturation of developing epithelia. In adult tissue, PCD plays a further role in the prevention of malignancy though removal of damaged cells. Here, we report that mutations in klumpfuss result in an excess of support cells during maturation of the developing Drosophila pupal retina. These ectopic cells are the result of a partial and specific failure of apoptotic death during normal cell fate selection. klumpfuss is required and differentially expressed in the cells that choose the life or death cell fate. We also provide genetic and biochemical evidence that klumpfuss regulates this process through down-regulation of the Epidermal Growth Factor Receptor/dRas1 signaling pathway. Based on its sequence Klumpfuss is an EGR-class nuclear factor, and our results suggest a mechanism by which mutations in EGR-class factors such as Wilms' Tumor Suppressor-1 may result in oncogenic events such as pediatric kidney tumors.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	In(1)rst³
Alleles (15)
	Ecol\lacZ^klu-09036 Ecol\lacZ^klu-10052 Egfr^E1 grim^GMR.PC klu^212lR51C klu¹⁰⁰⁵² klu^hs.PY klu^P21251A klu^Scer\UAS.cYa klu^unspecified Ras85D^V12.hs Ras85D^V12.sev rpr^GMR.PW Scer\GAL4^GMR.PF W^GMR.PG
Constructs (8)
	P{GAL4-ninaE.GMR} P{GMR-grim} P{GMR-hid} P{GMR-rpr.W} P{hsp70-klu.Y} P{hsRas1.V12} P{sevRas1.V12} P{UAS-klu.Y}
Genes (12)
	aos arm Ecol\lacZ Egfr grim klu Ras85D rl rpr rst Scer\GAL4 W
Insertions (2)
	P{PZ}klu⁰⁹⁰³⁶ P{PZ}klu¹⁰⁰⁵²