Reference Report

Reference
Citation	Tsai, Y.C., Sun, Y.H. (2004). Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development. genesis 39(2): 141--153. (Export to RIS)
FlyBase ID	FBrf0179489
Publication Type	Research paper
PubMed ID	15170700
PubMed Abstract	unpaired (upd) encodes a ligand for the Jak/STAT signaling pathway in Drosophila. In the second instar and early third larval eye disc, upd is expressed in the center of the posterior margin. upd loss-of-function mutations caused eye size reduction and upd overexpression caused eye enlargement. Upd regulates eye size through the Dome/Jak(Hop)/STAT92 signaling pathway to promote cell proliferation. Interestingly, the effect of Upd is only on cells located anterior to the morphogenetic furrow (MF), but has no effect on the second mitotic wave, which is posterior to MF. Overexpression of upd behind MF can nonautonomously induce cell proliferation up to 20 rows of cells anterior to MF. The G1 cyclin, cycD transcript level was also enhanced anterior to MF. Consistent with the long-range effect, we found that the extracellular Upd protein can be detected over a comparable long range, suggesting that Upd acts directly over a long distance as a signaling molecule.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	genesis
Title	genesis
Publication Year	2000-
ISBN/ISSN	1526-954X 1526-968X
Data from Reference
Aberrations (1)
	Df(1)os1A2
Alleles (30)
	BacA\p35^Scer\UAS.cHa dome^{Scer\UAS.cCGHa} dome^{ΔCYT.Scer\UAS} Ecol\lacZ^fng-35UZ-1 Ecol\lacZ^os-PD Ecol\lacZ^svp-AE127 fj^p1 fj^Scer\UAS.cZa hop²⁵ hop²⁹ hop^Scer\UAS.cHa hop^Tum.Scer\UAS os¹ os^o os^s os^Scer\UAS.cZa os^{Scer\UAS.T:Avic\GFP-EGFP} os^t10 os^UE69 os^upd-1 Scer\GAL4^Act5C.PI Scer\GAL4^bi-omb-Gal4 Scer\GAL4^dpp.blk1 Scer\GAL4^Eq1 Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^upd-E132 Stat92E⁰⁶³⁴⁶ Stat92E^HJ Stat92E^hs.PY
Constructs (14)
	P{Act5C-GAL4} P{GAL4-dpp.blk1} P{GAL4-ey.H} P{GAL4-ninaE.GMR} P{heat.shock/stat⁺} P{sisC.10} P{UAS-dome.CGH} P{UAS-dome.ΔCYT} P{UAS-fj} P{UAS-hop.H} P{UAS-hop.Tum} P{UAS-os.Z} P{UAS-p35.H} P{UAS-upd.EGFP}
Genes (10)
	BacA\p35 CycD dome Ecol\lacZ fj hop os Scer\GAL4 Stat92E T:Avic\GFP
Insertions (6)
	P{35UZ}fng^35UZ-1 P{GAL4}bi^omb-Gal4 P{GAL4-Hsp70.PB}l(3)Eq1^Eq1 P{GawB}E132 P{lacW}PD P{lwB}svp^AE127