Reference Report

Reference
Citation	Suh, G.S.B., Wong, A.M., Hergarden, A.C., Wang, J.W., Simon, A.F., Benzer, S., Axel, R., Anderson, D.J. (2004). A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Nature 431(7010): 854--859. (Export to RIS)
FlyBase ID	FBrf0179739
Publication Type	Research paper
PubMed ID	15372051
PubMed Abstract	All animals exhibit innate behaviours in response to specific sensory stimuli that are likely to result from the activation of developmentally programmed neural circuits. Here we observe that Drosophila exhibit robust avoidance to odours released by stressed flies. Gas chromatography and mass spectrometry identifies one component of this 'Drosophila stress odorant (dSO)' as CO2. CO2 elicits avoidance behaviour, at levels as low as 0.1%. We used two-photon imaging with the Ca2+-sensitive fluorescent protein G-CaMP to map the primary sensory neurons governing avoidance to CO2. CO2 activates only a single glomerulus in the antennal lobe, the V glomerulus; moreover, this glomerulus is not activated by any of 26 other odorants tested. Inhibition of synaptic transmission in sensory neurons that innervate the V glomerulus, using a temperature-sensitive Shibire gene (Shi(ts)), blocks the avoidance response to CO2. Inhibition of synaptic release in the vast majority of other olfactory receptor neurons has no effect on this behaviour. These data demonstrate that the activation of a single population of sensory neurons innervating one glomerulus is responsible for an innate avoidance behaviour in Drosophila.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (10)
	Avic\GFP^{GCaMP1.3.Scer\UAS.cAa} Scer\GAL4^103Y Scer\GAL4^c747 Scer\GAL4^ey-OK107 Scer\GAL4^GH146 Scer\GAL4^Gr21a.9.323 Scer\GAL4^Or47b.7.467 Scer\GAL4^{Orco.2.642.T:Hsim\VP22} shi^1.Scer\UAS T:Avic\GFP^cpEGFP
Constructs (5)
	P{Gr21a-GAL4.9.323} P{Or47b-GAL4.7.467} P{Orco-GAL4.W} P{UAS-GCaMP1.3.A} P{UAS-shi^ts1.K}
Genes (8)
	Avic\GFP Gr21a Or47b Orco Scer\GAL4 shi T:Avic\GFP T:Hsim\VP22
Insertions (4)
	P{GawB}103Y P{GawB}c747 P{GawB}ey^OK107 P{GawB}GH146
Transcripts (6)
	Scer\GAL4^103YRA Scer\GAL4^c761RA Scer\GAL4^GH146RA Scer\GAL4^Gr21a.9.323RA Scer\GAL4^Or47b.7.467RA Scer\GAL4^{Orco.2.642.T:Hsim\VP22}RA