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Citation
Hipfner, D.R., Keller, N., Cohen, S.M. (2004). Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth.  Genes Dev. 18(18): 2243--2248.
FlyBase ID
FBrf0179743
Publication Type
Research paper
Abstract

The Drosophila Sterile-20 kinase Slik promotes tissue growth during development by stimulating cell proliferation and by preventing apoptosis. Proliferation within an epithelial sheet requires dynamic control of cellular architecture. Epithelial integrity fails in slik mutant imaginal discs. Cells leave the epithelium and undergo apoptosis. The abnormal behavior of slik mutant cells is due to failure to phosphorylate and activate Moesin, which leads to excess Rho1 activity. This is distinct from Slik's effects on cell proliferation, which are mediated by Raf. Thus Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth.

PubMed ID
PubMed Central ID
PMC517517 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (12)
    Genes (8)
    Insertions (2)
    Experimental Tools (1)
    Transgenic Constructs (6)