Reference Report

Reference
Citation	Hayashi, T., Carthew, R.W. (2004). Surface mechanics mediate pattern formation in the developing retina. Nature 431(7009): 647--652. (Export to RIS)
FlyBase ID	FBrf0179748
Publication Type	Research paper
PubMed ID	15470418
PubMed Abstract	Pattern formation of biological structures involves organizing different types of cells into a spatial configuration. In this study, we investigate the physical basis of biological patterning of the Drosophila retina in vivo. We demonstrate that E- and N-cadherins mediate apical adhesion between retina epithelial cells. Differential expression of N-cadherin within a sub-group of retinal cells (cone cells) causes them to form an overall shape that minimizes their surface contact with surrounding cells. The cells within this group, in both normal and experimentally manipulated conditions, pack together in the same way as soap bubbles do. The shaping of the cone cell group and packing of its components precisely imitate the physical tendency for surfaces to be minimized. Thus, simple patterned expression of N-cadherin results in a complex spatial pattern of cells owing to cellular surface mechanics.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (1)
	In(2L)Roi¹
Alleles (11)
	amos^Roi-1 CadN^M12 CadN^M19 CadN^Scer\UAS.cIa Scer\GAL4^Act5C.PI Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL4^αTub84B.PL Scer\GAL80^αTub84B.PL shg^R69 shg^{Scer\UAS.T:Avic\GFP-rs} T:Avic\GFP^rs
Constructs (6)
	P{Act5C-GAL4} P{AyGAL4} P{tubP-GAL4} P{tubP-GAL80} P{UAS-CadN.I} P{UAS-shg.DEFL}
Genes (10)
	amos arm B-H1 CadN ct kst Scer\GAL4 Scer\GAL80 shg T:Avic\GFP