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Citation
Hayashi, T., Carthew, R.W. (2004). Surface mechanics mediate pattern formation in the developing retina.  Nature 431(7009): 647--652.
FlyBase ID
FBrf0179748
Publication Type
Research paper
Abstract
Pattern formation of biological structures involves organizing different types of cells into a spatial configuration. In this study, we investigate the physical basis of biological patterning of the Drosophila retina in vivo. We demonstrate that E- and N-cadherins mediate apical adhesion between retina epithelial cells. Differential expression of N-cadherin within a sub-group of retinal cells (cone cells) causes them to form an overall shape that minimizes their surface contact with surrounding cells. The cells within this group, in both normal and experimentally manipulated conditions, pack together in the same way as soap bubbles do. The shaping of the cone cell group and packing of its components precisely imitate the physical tendency for surfaces to be minimized. Thus, simple patterned expression of N-cadherin results in a complex spatial pattern of cells owing to cellular surface mechanics.
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PubMed Central ID
Related Publication(s)
Review
Developmental biology: Holding it together in the eye.
Janmey and Discher, 2004, Nature 431(7009): 635--636 [FBrf0179747]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference
    Aberrations (1)
    Alleles (10)
    Genes (9)
    Transgenic Constructs (6)