Reference Report

Reference
Citation	Kouzmenko, A.P., Takeyama, K., Ito, S., Furutani, T., Sawatsubashi, S., Maki, A., Suzuki, E., Kawasaki, Y., Akiyama, T., Tabata, T., Kato, S. (2004). Wnt/β-catenin and estrogen signaling converge in vivo. J. Biol. Chem. 279(39): 40255--40258. (Export to RIS)
FlyBase ID	FBrf0179825
Publication Type	Research paper
PubMed ID	15304487
PubMed Abstract	Wnt and estrogen signaling represent important regulatory pathways, each controlling a wide range of biological processes. While an increasing number of observations suggest potential convergence between these pathways, no direct evidence of their functional interaction has been reported. Using human colon and breast cancer cells, we found that estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes, reciprocally enhanced the transactivation of cognate reporter genes, and were reciprocally recruited to cognate response elements in the promoters of endogenous target genes. Using transgenic Drosophila that ectopically expressed human ERalpha alone or together with metabolically stable beta-catenin/Armadillo mutants, we demonstrated genetic interaction between these signal transducers in vivo. Thus, we present here the first direct evidence of cross-talk between Wnt and estrogen signaling pathways via functional interaction between beta-catenin and ERalpha.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Biol. Chem.
Title	Journal of Biological Chemistry
Publication Year	1905-
ISBN/ISSN	0021-9258
Data from Reference
Alleles (6)
	arm^{S10.Scer\UAS.T:Hsap\MYC} arm^{Δ.Scer\UAS.T:Ivir\HA1} Avic\GFP^ERE.cKa Hsap\ESR1^{1-302.Scer\UAS} Hsap\ESR1^Scer\UAS.cKa Scer\GAL4^GMR.PY
Constructs (6)
	P{ERE-GFP.K} P{GMR-GAL4.Y} P{UAS-arm.S10} P{UAS-arm.Δ.flu} P{UAS-ERα.1-302} P{UAS-ERα.K}
Genes (7)
	arm Avic\GFP GMR Hsap\ESR1 Scer\GAL4 T:Hsap\MYC T:Ivir\HA1