Reference Report

Reference
Citation	Emoto, K., He, Y., Ye, B., Grueber, W.B., Adler, P.N., Jan, L.Y., Jan, Y.N. (2004). Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119(2): 245--256. (Export to RIS)
FlyBase ID	FBrf0180024
Publication Type	Research paper
PubMed ID	15479641
PubMed Abstract	To cover the receptive field completely but without redundancy, neurons of certain functional groups exhibit tiling of their dendrites via dendritic repulsion. Here we show that two evolutionarily conserved proteins, the Tricornered (Trc) kinase and Furry (Fry), are essential for tiling and branching control of Drosophila sensory neuron dendrites. Dendrites of fry and trc mutants display excessive terminal branching and fail to avoid homologous dendritic branches, resulting in significant overlap of the dendritic fields. Trc control of dendritic branching involves regulation of RacGTPase, a pathway distinct from the action of Trc in tiling. Timelapse analysis further reveals a specific loss of the ability of growing dendrites to turn away from nearby dendritic branches in fry mutants, suggestive of a defect in like-repels-like avoidance. Thus, the Trc/Fry signaling pathway plays a key role in patterning dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching.
DOI
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Personal communication to FlyBase	Merge of UAS-trc[K122A] transgenes. Adler, 2010.9.10, Merge of UAS-trc[K122A] transgenes. [FBrf0211805]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (15)
	Avic\GFP^1.E.ppk fry¹ fry⁰²²⁴⁰ fry^KY319 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rac1^N17.Scer\UAS Rac1^Scer\UAS.cLa RhoL^N25.Scer\UAS Scer\GAL4⁴⁷⁷ trc¹ trc^{K122A.Scer\UAS.T:Zzzz\FLAG} trc^MtnA.PC trc^{S292A.T449A.Scer\UAS.T:Zzzz\FLAG} trc^S066917a trc^{Scer\UAS.T:Zzzz\FLAG}
Constructs (8)
	P{ppk-EGFP.1} P{UAS-mCD8::GFP.L} P{UAS-Rac1.L} P{UAS-Rac1.N17} P{UAS-RhoL.N25} P{UAS-trc.FLAG} P{UAS-trc.K122A} P{UAS-trc.S292A.T449A.FLAG}
Genes (10)
	Avic\GFP Cdc42 fry Mmus\Cd8a Rac1 RhoL Scer\GAL4 T:Avic\GFP T:Zzzz\FLAG trc
Insertions (2)
	P{GawB}477 P{GawB}fry^KY319