Reference Report

Reference
Citation	Song, Y.H., Mirey, G., Betson, M., Haber, D.A., Settleman, J. (2004). The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Curr. Biol. 14(15): 1354--1359. (Export to RIS)
FlyBase ID	FBrf0180054
Publication Type	Research paper
PubMed ID	15296752
PubMed Abstract	Cells of metazoan organisms respond to DNA damage by arresting their cell cycle to repair DNA, or they undergo apoptosis. Two protein kinases, ataxia-telangiectasia mutated (ATM) and ATM and Rad-3 related (ATR), are sensors for DNA damage. In humans, ATM is mutated in patients with ataxia-telangiectasia (A-T), resulting in hypersensitivity to ionizing radiation (IR) and increased cancer susceptibility. Cells from A-T patients exhibit chromosome aberrations and excessive spontaneous apoptosis. We used Drosophila as a model system to study ATM function. Previous studies suggest that mei-41 corresponds to ATM in Drosophila; however, it appears that mei-41 is probably the ATR ortholog. Unlike mei-41 mutants, flies deficient for the true ATM ortholog, dATM, die as pupae or eclose with eye and wing abnormalities. Developing larval discs exhibit substantially increased spontaneous chromosomal telomere fusions and p53-dependent apoptosis. These developmental phenotypes are unique to dATM, and both dATM and mei-41 have temporally distinct roles in G2 arrest after IR. Thus, ATM and ATR orthologs are required for different functions in Drosophila; the developmental defects resulting from absence of dATM suggest an important role in mediating a protective checkpoint against DNA damage arising during normal cell proliferation and differentiation.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (2)
	Df(3R)Hsc70-4^Δ11 Df(3R)Hsc70-4^Δ356
Alleles (10)
	Hsc70-4^+t14 Hsc70-4^EP859 Hsc70-4^Δ11 mei-41^D3 mei-41^unspecified p53^{R155H.Scer\UAS.Ex} Scer\GAL4^en-e16E tefu^unspecified tefu^Δ11 tefu^Δ356
Constructs (2)
	P{Hsc70-4.14} P{UAS-p53.R155H.Ex}
Genes (10)
	CG6499 His3 Hsc70-4 mei-41 Nipped-A nonC p53 Scer\GAL4 tefu Tor
Insertions (2)
	P{en2.4-GAL4}e16E P{EP}Hsc70-4^EP859