Reference Report

Reference
Citation	Dunlop, J., Morin, X., Corominas, M., Serras, F., Tear, G. (2004). glaikit is essential for the formation of epithelial polarity and neuronal development. Curr. Biol. 14(22): 2039--2045. (Export to RIS)
FlyBase ID	FBrf0180073
Publication Type	Research paper
PubMed ID	15556867
PubMed Abstract	Epithelial cells have a distinctive polarity based on the restricted distribution of proteins and junctional complexes along an apical-basal axis. Studying the formation of the polarized ectoderm of the Drosophila embryo has identified a number of the molecules that establish this polarity. The Crumbs (Crb) complex is one of three separate complexes that cooperate to control epithelial polarity and the formation of zonula adherens. Here we show that glaikit (gkt), a member of the phospholipase D superfamily, is essential for the formation of epithelial polarity and for neuronal development during Drosophila embryogenesis. In epithelial cells, gkt acts to localize the Crb complex of proteins to the apical lateral membrane. Loss of gkt during neuronal development leads to a severe CNS architecture disruption that is not dependent on the Crb pathway but probably results from the disrupted localization of other membrane proteins. A mutation in the human homolog of gkt causes the neurodegenerative disease spinocerebellar ataxia with neuropathy (SCAN1), making it possible that a failure of membrane protein localization is a cause of this disease.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (18)
	Avic\GFP^Lac-G00044 Avic\GFP^Nrg-G00305 baz⁴ Btau\MAPT^{Sema-2b.T:Hsap\MYC} CG3347^KG05281 crb^11A22 dlg1¹⁵ gkt^A12 gkt^dsRNA.cDa gkt^G85 gkt^k00223 gkt^Scer\UAS.cDa Mad² Mad^B1 Mad^k00223 Scer\GAL4^da.G32 Scer\GAL4^elav-C155 sdt^EH681
Constructs (3)
	P{GAL4-da.G32} P{Sema-2b-tau-myc} P{UAS-gkt.D}
Genes (22)
	Avic\GFP baz Btau\MAPT CG3347 crb dlg1 en eve Fas2 gkt hb insc Lac Mad mira Nrg Nrt raps Scer\GAL4 sdt shg T:Hsap\MYC
Insertions (6)
	P{GawB}elav^C155 P{lacW}Mad^B1 P{lacW}Mad^k00223 P{PTT-GA}Nrg^G00305 P{PTT-un1}Lac^G00044 P{SUPor-P}CG3347^KG05281