Reference Report

Reference
Citation	Adler, P.N., Zhu, C., Stone, D. (2004). Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins. Curr. Biol. 14(22): 2046--2051. (Export to RIS)
FlyBase ID	FBrf0180074
Publication Type	Research paper
PubMed ID	15556868
PubMed Abstract	Planar polarity development in the Drosophila wing is under the control of the frizzled (fz) pathway. Recent work has established that the planar polarity (PP) proteins become localized to either the distal, proximal, or both sides of wing cells. Fz and Dsh distal accumulation is thought to locally activate the cytoskeleton to form a hair . Planar polarity effector (PPE) genes such as inturned (in) are not required for the asymmetric accumulation of PP proteins, but they are required for this to influence hair polarity. in mutations result in abnormal hair polarity and are epistatic to mutations in the PP genes. We report that In localizes to the proximal side of wing cells in a PP-dependent and PP-instructive manner. We further show that the function of two other PPE genes (fuzzy and fritz) is essential for In protein localization, a finding consistent with previous genetic data that suggested these three genes function in a common process. These data indicate that accumulation of proteins at the proximal side of wing cells is a key event for the distal activation of the cytoskeleton to form a hair.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (15)
	Avic\GFP^Scer\UAS.cUa ds^unspecified frtz^unspecified fy^unspecified fz^{arm.T:Avic\GFP-EGFP} grh^unspecified in^unspecified mwh^unspecified pk^Scer\UAS.cGa pk^unspecified Scer\GAL4^ptc-559.1 stan^Scer\UAS.cUa stan^unspecified T:Avic\GFP^EGFP Vang^unspecified
Constructs (4)
	P{arm-fz.GFP} P{UAS-fmi.U} P{UAS-GFP.U} P{UAS-pk.G}
Genes (12)
	Avic\GFP ds frtz fy fz grh in mwh pk Scer\GAL4 stan Vang
Insertions (1)
	P{GawB}ptc^559.1