Reference Report

Reference
Citation	Inbal, A., Volk, T., Salzberg, A. (2004). Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. Dev. Cell 7(2): 241--250. (Export to RIS)
FlyBase ID	FBrf0180120
Publication Type	Research paper
PubMed ID	15296720
PubMed Abstract	Drosophila proprioceptors (chordotonal organs) are structured as a linear array of four lineage-related cells: a neuron, a glial cell, and two accessory cells, called cap and ligament, between which the neuron is stretched. To function properly as stretch receptors, chordotonal organs must be stably anchored at both edges. The cap cells are anchored to the cuticle through specialized lineage-related attachment cells. However, the mechanism by which the ligament cells at the other edge of the organ attach is not known. Here, we report the identification of specialized attachment cells that anchor the ligament cells of pentascolopidial chordotonal organs (lch5) to the cuticle. The ligament attachment cells are recruited by the approaching ligament cells upon reaching their attachment site, through an EGFR-dependent mechanism. Molecular characterization of lch5 attachment cells demonstrated that they share significant properties with Drosophila tendon cells and with mammalian proprioceptive organs.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (20)
	abd-A^D24 Ecol\lacZ^rho-X81 Ecol\lacZ^Scer\UAS.cUa Egfr^DN.Scer\UAS en::hth^{1-430.Scer\UAS} gcm^N7-4 repo⁰³⁷⁰² rho^PΔ38 rpr^Scer\UAS.C Scer\GAL4^69B Scer\GAL4^ato.3.6 Scer\GAL4^repo Scer\GAL4^sr-md710 spi³ spi^s.Scer\UAS sr¹⁵⁵ sr⁰³⁹⁹⁹ vn¹⁰⁵⁶⁷ vn^Scer\UAS.cYa vvl^H599
Constructs (6)
	P{ato-GAL4.3.6} P{UAS-Egfr.DN} P{UAS-en-hth.1-430} P{UAS-rpr.C} P{UAS-spi.s} P{UAS-vn.Y}
Genes (18)
	abd-A ato Ecol\lacZ Egfr en::hth Fas3 gcm repo rho rpr Scer\GAL4 spi sr tx vn vvl αTub85E βTub56D
Insertions (4)
	P{GAL4}repo P{GawB}69B P{GawB}sr^md710 P{lwB}X81
Transcripts (2)
	Scer\GAL4^ato.3.6RA Scer\GAL4^sr-md710RA