Reference Report

Reference
Citation	Bajpai, R., Sambrani, N., Stadelmayer, B., Shashidhara, L.S. (2004). Identification of a novel target of D/V signaling in Drosophila wing disc: wg-independent function of the organizer. Gene Expr. Patterns 5(1): 113--121. (Export to RIS)
FlyBase ID	FBrf0180230
Publication Type	Research paper
PubMed ID	15533826
PubMed Abstract	Growth and patterning during Drosophila wing development are mediated by signaling from its dorso-ventral (D/V) organizer. Wingless is expressed in the D/V boundary and functions as a morphogen to activate target genes at a distance. Wingless pathway and thereby D/V signaling is negatively regulated by the homeotic gene Ultrabithorax (Ubx) to mediate haltere development. In an enhancer-trap screen to identify genes that show differential expression between wing and haltere discs, we identified CG32062, which codes for a RNA-binding protein. In wing discs, CG32062 is expressed only in non-D/V cells. CG32062 expression in non-D/V cells is dependent on Notch-mediated signaling from the D/V boundary. However, CG32062 expression is independent of Wingless function, thus providing evidence for a second long-range signaling mechanism of the D/V organizer. In haltere discs, CG32062 is negatively regulated by Ubx. The non-cell autonomous nature of Ubx-mediated repression of CG32062 expression suggests that the novel component of D/V signaling is also negatively regulated during haltere specification.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Gene Expr. Patterns
Title	Gene expression patterns : GEP
Publication Year	2002-
ISBN/ISSN	1567-133X 1872-7298
Data from Reference
Alleles (42)
	A2bp1^EN403-GAL4 A2bp1^EN403-lacZ aos^Scer\UAS.cMa arm⁸ Avic\GFP^Scer\UAS.cUa btl::Egfr^{Scer\UAS.T:λ\cI-DD} dpp^Scer\UAS.cFa dsh^Scer\UAS.cNa Ecol\lacZ^{A2bp1-EN403-lacZ} Ecol\lacZ^arm.PV Ecol\lacZ^Scer\UAS.cUa Egfr^DN.Scer\UAS fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} Hsap\APC^CBD.Scer\UAS N^{int.G.Scer\UAS} N^l1N-ts1 pan^ΔN.Scer\UAS Ras85D^{G13Q.Scer\UAS} Ras85D^N17.Scer\UAS Scer\GAL4⁴²⁶ Scer\GAL4^{A2bp1-EN403-GAL4} Scer\GAL4^bi-md653 Scer\GAL4^dpp.blk1 Scer\GAL4^ptc-559.1 Scer\GAL4^vg.PM Ser^{S.Scer\UAS.T:Hsap\MYC} sgg^Scer\UAS.cSa T:λ\cI^DD Ubx¹ Ubx^abx-1 Ubx^bx-3 Ubx^Cbx-Hm Ubx^pbx-1 Ubx^Scer\UAS.cCa vg¹ wg^Scer\UAS.cLa Wnt2^Scer\UAS.cSa Wnt4^Scer\UAS.cGa Wnt5^Scer\UAS.cSa Wnt6^Scer\UAS.cSa Wnt10^Scer\UAS.cSa wntD^Scer\UAS.cSa
Constructs (26)
	P{arm-lacZ.V} P{GAL4-dpp.blk1} P{GAL4-vg.M} P{UAS-APC.CBD} P{UAS-argos.M} P{UAS-dpp.BEH1} P{UAS-dsh.N} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-fz2(ECD)-GPI} P{UAS-GFP.U} P{UAS-lacZ.U} P{UAS-N.intra.G} P{UAS-pan.dTCFΔN} P{UAS-Ras85B.Act} P{UAS-Ras85D.N17} P{UAS-Ser.S} P{UAS-sgg.S} P{UAS-Ubx.Ia.C} P{UAS-wg.L} P{UAS-Wnt2.S} P{UAS-Wnt4.G} P{UAS-Wnt5.S} P{UAS-Wnt6.S} P{UAS-Wnt10.S} P{UAS-wntD.S}
Genes (29)
	A2bp1 aos arm Avic\GFP btl::Egfr dpp dsh Ecol\lacZ Egfr en fz2 Hsap\APC N pan Ras85D Scer\GAL4 Ser sgg T:Hsap\MYC T:λ\cI Ubx vg wg Wnt2 Wnt4 Wnt5 Wnt6 Wnt10 wntD
Insertions (5)
	P{GAL4}426 P{GAL4}A2bp1^EN403-GAL4 P{GawB}bi^md653 P{GawB}ptc^559.1 P{lacZ}A2bp1^EN403-lacZ