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Citation
Milchanowski, A.B., Henkenius, A.L., Narayanan, M., Hartenstein, V., Banerjee, U. (2004). Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis.  Genetics 168(1): 325--339.
FlyBase ID
FBrf0180297
Publication Type
Research paper
Abstract
Parallels between vertebrate and Drosophila hematopoiesis add to the value of flies as a model organism to gain insights into blood development. The Drosophila hematopoietic system is composed of at least three classes of terminally differentiated blood cells: plasmatocytes, crystal cells, and lamellocytes. Recent studies have identified transcriptional and signaling pathways in Drosophila involving proteins similar to those seen in human blood development. To identify additional genes involved in Drosophila hematopoiesis, we have conducted a P-element-based genetic screen to isolate mutations that affect embryonic crystal cell development. Using a marker of terminally differentiated crystal cells, we screened 1040 P-element-lethal lines located on the second and third chromosomes and identified 44 individual lines that affect crystal cell development. Identifying novel genes and pathways involved in Drosophila hematopoiesis is likely to provide further insights into mammalian hematopoietic development and disorders.
PubMed ID
PubMed Central ID
PMC1448098 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Alleles (88)
    Genes (75)
    Insertions (12)
    Transgenic Constructs (5)