Reference Report

Reference
Citation	Kumar, J.P., Jamal, T., Doetsch, A., Turner, F.R., Duffy, J.B. (2004). CREB binding protein functions during successive stages of eye development in Drosophila. Genetics 168(2): 877--893. (Export to RIS)
FlyBase ID	FBrf0180303
Publication Type	Research paper
PubMed ID	15514061
PubMed Abstract	During the development of the compound eye of Drosophila several signaling pathways exert both positive and inhibitory influences upon an array of nuclear transcription factors to produce a near-perfect lattice of unit eyes or ommatidia. Individual cells within the eye are exposed to many extracellular signals, express multiple surface receptors, and make use of a large complement of cell-subtype-specific DNA-binding transcription factors. Despite this enormous complexity, each cell will make the correct developmental choice and adopt the appropriate cell fate. How this process is managed remains a poorly understood paradigm. Members of the CREB binding protein (CBP)/p300 family have been shown to influence development by (1) acting as bridging molecules between the basal transcriptional machinery and specific DNA-binding transcription factors, (2) physically interacting with terminal members of signaling cascades, (3) acting as transcriptional coactivators of downstream target genes, and (4) playing a key role in chromatin remodeling. In a screen for new genes involved in eye development we have identified the Drosophila homolog of CBP as a key player in both eye specification and cell fate determination. We have used a variety of approaches to define the role of CBP in eye development on a cell-by-cell basis.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (27)
	Avic\GFP^Scer\UAS.cUa Ecol\lacZ^so-7 nej³ nej¹³¹ nej^{dsRNA.Scer\UAS.cKa} nej^{F2161A.Scer\UAS.T:SV5\V5} nej^KIX.Scer\UAS nej^P nej^Q7 nej^S103 nej^S342 nej^{Scer\UAS.T:SV5\V5} nej^TA57 nej^TC41 nej^{ΔBHQ.Scer\UAS} nej^{ΔHQ.Scer\UAS} nej^{ΔNZK.Scer\UAS} nej^ΔQ.Scer\UAS Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^lz-gal4 Scer\GAL4^unspecified so¹ so³ so^D w^+mC
Constructs (12)
	P{GAL4-ey.H} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{UAS-GFP.U} P{UAS-nej.F2161A-V5} P{UAS-nej.KIX} P{UAS-nej.RNAi} P{UAS-nej.wt-V5} P{UAS-nej.ΔBHQ} P{UAS-nej.ΔHQ} P{UAS-nej.ΔNZK} P{UAS-nej.ΔQ}
Genes (16)
	ato Avic\GFP ci dac dpp Ecol\lacZ elav eya lz Mad nej pan Scer\GAL4 so T:SV5\V5 w
Insertions (2)
	P{A92}so⁷ P{GawB}lz^gal4