Open Close
Munier, A.I., Medzhitov, R., Janeway, C.A., Doucet, D., Capovilla, M., Lagueux, M. (2004). graal: a Drosophila gene coding for several mosaic serine proteases.  Insect Biochem. Mol. Biol. 34(10): 1025--1035.
FlyBase ID
Publication Type
Research paper

Serine proteases play vital roles in several biological processes such as development and immunity. We have characterized Graal, a large multi-domain serine protease from Drosophila. Graal is spliced in at least three transcripts that are present throughout development. The domains found in Graal proteins are: chitin-binding domains (CBD), scavenger receptor cysteine-rich (SRCR) domains, low density lipoprotein receptor cysteine-rich (LDLR-CR) domains, histidine and proline-rich domains, a NGGYQPP-repeat domain and a serine protease domain. The last 2370 nucleotides of these RNAs are identical and encode a His-rich domain, two SRCR domains, two LDLR-CR domains and a protease domain. The transcription of graal is upregulated after fungal or bacterial infection. Analysis of the Iso1 (y;cn,sp,bw) strain shows that graal transcription is impaired in this fly line due to the insertion of a retrotransposon in the sixth exon. However, no phenotype could be observed consecutive to the absence of graal full length transcripts, particularly in the context of an immune challenge.

PubMed ID
PubMed Central ID
Associated Information
Associated Files
Other Information
Secondary IDs
    Language of Publication
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Insect Biochem. Mol. Biol.
    Insect Biochemistry and Molecular Biology
    Publication Year
    Data From Reference
    Aberrations (5)
    Alleles (6)
    Genes (16)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (3)