Reference Report

Reference
Citation	Albin, S.D., Davis, G.W. (2004). Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. J. Neurosci. 24(31): 6871--6879. (Export to RIS)
FlyBase ID	FBrf0180421
Publication Type	Research paper
PubMed ID	15295021
PubMed Abstract	Here, we show that postsynaptic p21-activated kinase (Pak) signaling diverges into two genetically separable pathways at the Drosophila neuromuscular junction. One pathway controls glutamate receptor abundance. Pak signaling within this pathway is specified by a required interaction with the adaptor protein Dreadlocks (Dock). We demonstrate that Dock is localized to the synapse via an Src homology 2-mediated protein interaction. Dock is not necessary for Pak localization but is necessary to restrict Pak signaling to control glutamate receptor abundance. A second genetically separable function of Pak kinase signaling controls muscle membrane specialization through the regulation of synaptic Discs-large. In this pathway, Dock is dispensable. We present a model in which divergent Pak signaling is able to coordinate two different features of postsynaptic maturation, receptor abundance, and muscle membrane specialization.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Aberrations (2)
	Df(2L)ast2 Df(3R)WIN11
Alleles (17)
	Cdc42^N17.Scer\UAS dock⁴ dock⁰⁴⁷²³ GluRIIA^SP16 Pak³ Pak⁴ Pak⁶ Pak¹¹ Pak^{Scer\UAS.T:Myr-Src64B} Pak^SH.Scer\UAS Pak^unspecified Rac1^N17.Scer\UAS Scer\GAL4^G14 Scer\GAL4^insc-Mz1407 Scer\GAL4^Mhc.PW trio^S138606 w^+mC
Constructs (4)
	P{GAL4-Mhc.W} P{UAS-Cdc42.N17} P{UAS-Pak.SH} P{UAS-Rac1.N17}
Genes (10)
	Cdc42 dlg1 dock GluRIIA Pak Rac1 Scer\GAL4 T:Myr-Src64B trio w
Insertions (2)
	P{GAL4}G14 P{GawB}insc^Mz1407
Natural transposons (1)
	P-element