Reference Report

Reference
Citation	Larsson, M.C., Domingos, A.I., Jones, W.D., Chiappe, M.E., Amrein, H., Vosshall, L.B. (2004). Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron 43(5): 703--714. (Export to RIS)
FlyBase ID	FBrf0180575
Publication Type	Research paper
PubMed ID	15339651
PubMed Abstract	Fruit flies are attracted by a diversity of odors that signal the presence of food, potential mates, or attractive egg-laying sites. Most Drosophila olfactory neurons express two types of odorant receptor genes: Or83b, a broadly expressed receptor of unknown function, and one or more members of a family of 61 selectively expressed receptors. While the conventional odorant receptors are highly divergent, Or83b is remarkably conserved between insect species. Two models could account for Or83b function: it could interact with specific odor stimuli independent of conventional odorant receptors, or it could act in concert with these receptors to mediate responses to all odors. Our results support the second model. Dendritic localization of conventional odorant receptors is abolished in Or83b mutants. Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Alleles (15)
	Ecol\lacZ^Scer\UAS.cUa Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.cEa.T:Avic\GFP} Or22a^Scer\UAS.cLb Orco¹ Orco² Orco³ Orco^EndsOut.L Orco^Scer\UAS.cLa Scer\GAL4^Or22a.7.717 Scer\GAL4^{Orco.2.642.T:Hsim\VP22} T:Avic\GFP^EGFP w^+* w^+mC
Constructs (9)
	P{EndsOut-Orco.L} P{Or22a-GAL4.7.717} P{Orco-GAL4.W} P{UAS-Hsap\KCNJ2.EGFP} P{UAS-lacZ.U} P{UAS-mCD8::GFP.L} P{UAS-n-syb-GFP.E} P{UAS-Or22a.L} P{UAS-Orco.L}
Genes (18)
	brp Ecol\lacZ futsch Hsap\KCNJ2 Mmus\Cd8a n-syb Or22a Or22b Or43a Or43b Or47a Or47b Or88a Orco Scer\GAL4 T:Avic\GFP T:Hsim\VP22 w
Natural transposons (1)
	P-element