Reference Report

Reference
Citation	Renault, A.D., Sigal, Y.J., Morris, A.J., Lehmann, R. (2004). Soma-germ line competition for lipid phosphate uptake regulates germ cell migration and survival. Science 305(5692): 1963--1966. (Export to RIS)
FlyBase ID	FBrf0180678
Publication Type	Research paper
PubMed ID	15331773
PubMed Abstract	Lipid phosphates can act as signaling molecules to influence cell division, apoptosis, and migration. wunen and wunen2 encode Drosophila lipid phosphate phosphohydrolases, integral membrane enzymes that dephosphorylate extracellular lipid phosphates. wun and wun2 act redundantly in somatic tissues to repel migrating germ cells, although the mechanism by which germ cells respond is unclear. Here, we report that wun2 also functions in germ cells, enabling them to perceive the wun/wun2-related signal from the soma. Upon Wun2 expression, cultured insect cells dephosphorylate and internalize exogenously supplied lipid phosphate. We propose that Drosophila germ cell migration and survival are controlled by competition for hydrolysis of a lipid phosphate between germ cells and soma.
DOI
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Supplementary material	Supporting Online Material. [FBrf0202565]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (1)
	Df(2R)wun-GL
Alleles (11)
	Ecol\lacZ^Scer\UAS.cUa Hsap\PPAP2B^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Mmus\Ppap2a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^{nos.UTR.T:Hsim\VP16} wun2^EP2650ex34 wun2^{H326K.Scer\UAS.T:Hsap\MYC} wun2^{Scer\UAS.T:Hsap\MYC} wun2^{Y225W.Scer\UAS.T:Hsap\MYC} wun2^{αTub84B.T:Hsap\MYC} wun^Scer\UAS.cZa
Constructs (10)
	P{GAL4::VP16-nos.UTR} P{UAS-hLPP3.EGFP} P{UAS-lacZ.U} P{UAS-mCD8::GFP.L} P{UAS-mLpp1.GFP} P{UAS-wun2.H326K} P{UAS-wun2.Myc} P{UAS-wun2.Y225W} P{UAS-wun.Z} P{αTub84B(-FRT)wun2.myc}
Genes (8)
	Ecol\lacZ Hsap\PPAP2B Mmus\Cd8a Mmus\Ppap2a Scer\GAL4 vas wun wun2