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Citation
Valencia-Sanchez, M.A., Maquat, L.E. (2004). An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA.  Trends Cell Biol. 14(11): 594--597.
FlyBase ID
FBrf0180691
Publication Type
Review
Abstract

Quality-control mechanisms function in cells to ensure proper gene expression. Nonsense-mediated mRNA decay (NMD) is one such mechanism and it degrades abnormal mRNAs that contain a premature-termination codon. Although NMD is conserved in all eukaryotes that have been examined, it can manifest mechanistic differences in different organisms. A recent study using Drosophila melanogaster describes a new mechanistic twist to NMD.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Trends Cell Biol.
    Title
    Trends in Cell Biology
    Publication Year
    1991-
    ISBN/ISSN
    0962-8924
    Data From Reference
    Genes (10)