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Cohen, M., Gruenbaum, Y., Lee, K.K., Wilson, K.L. (2001). Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina.  Trends Biochem. Sci. 26(1): 41--47.
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FBrf0182679
Publication Type
Review
Abstract
The number and complexity of genes encoding nuclear lamina proteins has increased during metazoan evolution. Emerging evidence reveals that transcriptional repressors such as the retinoblastoma protein, and apoptotic regulators such as CED-4, have functional and dynamic interactions with the lamina. The discovery that mutations in nuclear lamina proteins cause heritable tissue-specific diseases, including Emery-Dreifuss muscular dystrophy, is prompting a fresh look at the nuclear lamina to devise models that can account for its diverse functions and dynamics, and to understand its enigmatic structure.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Compendium
    Abbreviation
    Trends Biochem. Sci.
    Title
    Trends in Biochemical Sciences
    Publication Year
    1976-
    ISBN/ISSN
    0167-7640 0968-0004
    Data From Reference
    Genes (7)