Reference Report

Reference
Citation	Lai, Z.C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L.L., Li, Y. (2005). Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120(5): 675--685. (Export to RIS)
FlyBase ID	FBrf0183777
Publication Type	Research paper
PubMed ID	15766530
PubMed Abstract	Appropriate cell number and organ size in a multicellular organism are determined by coordinated cell growth, proliferation, and apoptosis. Disruption of these processes can cause cancer. Recent studies have identified the Large tumor suppressor (Lats)/Warts (Wts) protein kinase as a key component of a pathway that controls the coordination between cell proliferation and apoptosis. Here we describe growth inhibitory functions for a Mob superfamily protein, termed Mats (Mob as tumor suppressor), in Drosophila. Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth. We show that mats and wts function in a common pathway. Mats physically associates with Wts to stimulate the catalytic activity of the Wts kinase. A human Mats ortholog (Mats1) can rescue the lethality associated with loss of Mats function in Drosophila. As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(3R)mats^e325
Alleles (15)
	Ecol\lacZ^th-j5C8 EP3303^EP3303 Hsap\MOB1A^{Scer\UAS.T:Hsap\MYC} mats^e235 mats^roo mats^Scer\UAS.cLa Scer\GAL4^arm.PS Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^αTub84B.PL th^j5C8 W^GMR.PG wts^GMR.PT wts^{Scer\UAS.L.T:Hsap\MYC} wts^x1
Constructs (9)
	P{GAL4-arm.S} P{GAL4-ey.H} P{GAL4-ninaE.GMR} P{GMR-hid} P{GMR-wts.T} P{tubP-GAL4} P{UAS-human.Mats1.MYC} P{UAS-mats.L} P{UAS-wts.L.MYC}
Genes (13)
	arm CycE Ecol\lacZ elav His3 Hsap\MOB1A mats pinta Scer\GAL4 T:Hsap\MYC th W wts
Insertions (2)
	P{lacW}th^j5C8 roo{}mats^roo