Reference Report

Reference
Citation	Shimmi, O., Umulis, D., Othmer, H., O'connor, M.B. (2005). Facilitated transport of a dpp/scw heterodimer by sog/tsg leads to robust patterning of the Drosophila blastoderm embryo. Cell 120(6): 873--886. (Export to RIS)
FlyBase ID	FBrf0183778
Publication Type	Research paper
PubMed ID	15797386
PubMed Abstract	Patterning the dorsal surface of the Drosophila blastoderm embryo requires Decapentaplegic (Dpp) and Screw (Scw), two BMP family members. Signaling by these ligands is regulated at the extracellular level by the BMP binding proteins Sog and Tsg. We demonstrate that Tsg and Sog play essential roles in transporting Dpp to the dorsal-most cells. Furthermore, we provide biochemical and genetic evidence that a heterodimer of Dpp and Scw, but not the Dpp homodimer, is the primary transported ligand and that the heterodimer signals synergistically through the two type I BMP receptors Tkv and Sax. We propose that the use of broadly distributed Dpp homodimers and spatially restricted Dpp/Scw heterodimers produces the biphasic signal that is responsible for specifying the two dorsal tissue types. Finally, we demonstrate mathematically that heterodimer levels can be less sensitive to changes in gene dosage than homodimers, thereby providing further selective advantage for using heterodimers as morphogens.
DOI
Related Publication(s)
Erratum	Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo (vol 120, pg 873, 2005). Shimmi et al., 2005, Cell 121(3): 493 [FBrf0187237]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(2L)OD16
Alleles (13)
	dpp^{genomic.T:Ivir\HA1} dpp^H48 dpp^{MtnA.T:Ivir\HA1} dpp^{Scer\UAS.cSa.T:Ivir\HA1} put^dsRNA.cSa sax^dsRNA.cSa scw^{Act5C.T:Zzzz\FLAG} sog^Scer\UAS.cYa sog^T:Hsap\MYC tkv^dsRNA.cSa tld^{MtnA.T:Ivir\HA1} tsg^T:Zzzz\His6 tsg^XB
Constructs (3)
	P{genomic-Dpp.HA} P{UAS-dpp.HA.S} P{UAS-sog.Y}
Genes (16)
	Ance dpp Mad pnr put sax Scer\GAL4 scw sog T:Hsap\MYC T:Ivir\HA1 T:Zzzz\FLAG T:Zzzz\His6 tkv tld tsg
Natural transposons (1)
	P-element