Reference Report

Reference
Citation	Shen, J., Dahmann, C. (2005). The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary. Dev. Biol. 279(1): 31--43. (Export to RIS)
FlyBase ID	FBrf0183859
Publication Type	Research paper
PubMed ID	15708556
PubMed Abstract	The subdivision of the developing Drosophila wing into anterior (A) and posterior (P) compartments is important for its development. The activities of the selector genes engrailed and invected in posterior cells and the transduction of the Hedgehog signal in anterior cells are required for maintaining the A/P boundary. Based on a previous study, it has been proposed that the signaling molecule Decapentaplegic (Dpp) is also important for this function by signaling from anterior to posterior cells. However, it was not known whether and in which cells Dpp signal transduction was required for maintaining the A/P boundary. Here, we have investigated the role of the Dpp signal transduction pathway and the epistatic relationship of Dpp and Hedgehog signaling in maintaining the A/P boundary by clonal analysis. We show that a transcriptional response to Dpp involving the T-box protein Optomotor-blind is required to maintain the A/P boundary. Further, we find that Dpp signal transduction is required in anterior cells, but not in posterior cells, indicating that anterior to posterior signaling by Dpp is not important for maintaining the A/P boundary. Finally, we provide evidence that Dpp signaling acts downstream of or in parallel with Hedgehog signaling to maintain the A/P boundary. We propose that Dpp signaling is required for anterior cells to interpret the Hedgehog signal in order to specify segregation properties important for maintaining the A/P boundary.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (2)
	Df(2L)32FP-5 Df(2L)flp147E
Alleles (14)
	Avic\GFP^Scer\UAS.cUa bi^omb-3198 brk^XH bsk^flp147E ci^Scer\UAS.cDa Ecol\lacZ^hh-P30 Mad¹² Mad^B1 Mad^αTub84B.PM sbb¹ sbb² Scer\GAL4^hh-Gal4 tkv⁴ tkv^Scer\UAS.cNa
Constructs (4)
	P{UAS-ci.D} P{UAS-GFP.U} P{UAS-tkv.Na} P{αTub84B-Mad.M}
Genes (17)
	Avic\GFP bi brk bsk ci dpp Ecol\lacZ en hh inv Mad ptc salm salr sbb Scer\GAL4 tkv
Insertions (3)
	P{GAL4}hh^Gal4 P{lacW}Mad^B1 P{PZ}hh^P30