Reference Report

Reference
Citation	Kojima, T., Tsuji, T., Saigo, K. (2005). A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Dev. Biol. 279(2): 434--445. (Export to RIS)
FlyBase ID	FBrf0183860
Publication Type	Research paper
PubMed ID	15733670
PubMed Abstract	The subdivision of the developing field by region-specific expression of genes encoding transcription factors is an essential step during appendage development in arthropod and vertebrates. In Drosophila leg development, the distal-most region (pretarsus) is specified by the expression of homeobox genes, aristaless and Lim1, and its immediate neighbor (distal tarsus) is specified by the expression of a pair of Bar homeobox genes. Here, we show that one additional gene, clawless, which is a homolog of vertebrate Hox11/tlx homeobox gene family and formerly known as C15, is specifically expressed in the pretarsus and cooperatively acts with aristaless to repress Bar and possibly to activate Lim1. Similar to aristaless, the maximal expression of clawless requires Lim1 and its co-factor, Chip. Bar attenuates aristaless and clawless expression through Lim1 repression. Aristaless and Clawless proteins form a complex capable of binding to specific DNA targets, which cannot be well recognized solely by Aristaless or Clawless.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (5)
	Ab(2;?)al^ice Df(3R)e-F1 Df(3R)e-GC3 Df(3R)e-H4 Df(3R)e-R1
Alleles (13)
	al^ex al^ice al^Scer\UAS.cKa Avic\GFP^Scer\UAS.cUa B-H1^Scer\UAS.cSa C15^cll-dl92 C15^Scer\UAS.cKa Chi^e5.5 Ecol\lacZ^Lim1-P0092 Lim1^7B2 Lim1^Scer\UAS.cTa Scer\GAL4^dpp.blk1 w^+mC
Constructs (6)
	P{GAL4-dpp.blk1} P{UAS-al.K} P{UAS-B-H1.S} P{UAS-C15.K} P{UAS-GFP.U} P{UAS-Lim1.T}
Genes (12)
	al Avic\GFP B-H1 C15 CG7056 CG7922 Chi Ecol\lacZ lbe Lim1 Scer\GAL4 w
Insertions (3)
	P{lArB}Lim1^P0092 P{UAS-C15.K}m22M P{UAS-C15.K}m212M