Reference Report

Reference
Citation	Pascual, A., Chaminade, M., Preat, T. (2005). Ethanolamine kinase controls neuroblast divisions in Drosophila mushroom bodies. Dev. Biol. 280(1): 177--186. (Export to RIS)
FlyBase ID	FBrf0183862
Publication Type	Research paper
PubMed ID	15766757
PubMed Abstract	The Drosophila mushroom bodies (MBs), paired brain structures composed of vertical and medial lobes, achieve their final organization at metamorphosis. The alpha lobe absent (ala) mutant randomly lacks either the vertical lobes or two of the median lobes. We characterize the ala axonal phenotype at the single-cell level, and show that the ala mutation affects Drosophila ethanolamine (Etn) kinase activity and induces Etn accumulation. Etn kinase is overexpressed in almost all cancer cells. We demonstrate that this enzymatic activity is required in MB neuroblasts to allow a rapid rate of cell division at metamorphosis, linking Etn kinase activity with mitotic progression. Tight control of the pace of neuroblast division is therefore crucial for completion of the developmental program in the adult brain.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(1)4b18
Alleles (7)
	eas² eas^alaE13 eas^alaP eas^hs.PP eas^Scer\UAS.cPa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^ey-OK107
Constructs (3)
	P{hs-eas.c12} P{UAS-eas.P} P{UAS-mCD8::GFP.L}
Genes (7)
	CG3560 eas Fas2 Mmus\Cd8a Prosα4 Scer\GAL4 T:Avic\GFP
Insertions (2)
	P{GawB}eas^alaP P{GawB}ey^OK107