Ishii, S. (2005). Costal-2: a scaffold for kinases mediates Hedgehog signaling.  Dev. Cell 8(2): 140--141.

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Note

Drosophila genetics has identified several components of the Hedgehog signaling pathway, but the mechanism by which they act remains elusive. In this issue of Developmental Cell, a report by Zhang et al. provides evidence that the kinesin-related protein Costal-2 forms a multi-component scaffold that mediates Hedgehog signaling.