Reference Report

Reference
Citation	Glise, B., Miller, C.A., Crozatier, M., Halbisen, M.A., Wise, S., Olson, D.J., Vincent, A., Blair, S.S. (2005). Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev. Cell 8(2): 255--266. (Export to RIS)
FlyBase ID	FBrf0183876
Publication Type	Research paper
PubMed ID	15691766
PubMed Abstract	We here identify and characterize an extracellular modulator of Hedgehog signaling in Drosophila, Shifted. Shifted is required for high levels of long-range signaling in the developing wing imaginal disc. Surprisingly, shifted encodes the only Drosophila ortholog of the secreted vertebrate protein Wnt Inhibitory Factor-1 (WIF-1), whose known role is to bind to extracellular Wnts and inhibit their activity. However, Shifted does not regulate Hedgehog signaling by affecting Wingless or Wnt signaling. We show instead that Shifted is a secreted protein that acts over a long distance and is required for the normal accumulation of Hh protein and its movement in the wing. Our data further indicate that Shf interacts with Hh and the heparan sulfate proteoglycans. Therefore, we propose that Shf stabilizes the interaction between Hh and the proteoglycans, an unexpected role for a member of the WIF-1 family.
DOI
Related Publication(s)
Review	Shifted from Wnt to Hedgehog signaling pathways. Han and Lin, 2005, Mol. Cell 17(3): 321--322 [FBrf0184149]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (1)
	Df(1)x13
Alleles (32)
	C3G^x13 dally⁸⁰ dlp^A187 dsh^Scer\UAS.cAa Ecol\lacZ^dpp.BS3.0 Ext2⁴⁴ hh^N.Scer\UAS hh^Scer\UAS.cIa hh^ts2 kn¹ kn^col-1 Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 shf² shf⁹¹⁹ shf^EY03173 shf^P1 shf^Scer\UAS.cGb shf^{Scer\UAS.T:Avic\GFP-EGFP} shf^x13 shf^x33 shf^{δEGF.Scer\UAS} shf^{δWIF.Scer\UAS} ttv⁶³ Wnt2^Scer\UAS.cSa Wnt5^Scer\UAS.cSa Wnt6^Scer\UAS.cSa Wnt10^Scer\UAS.cSa wntD^Scer\UAS.cSa
Constructs (14)
	P{BS3.0} P{CaSpeR} P{GAL4-dpp.blk1} P{UAS-dsh.A} P{UAS-hh.I} P{UAS-hh.N} P{UAS-shf.Gb} P{UAS-shf.δEGF} P{UAS-shf-EGFP} P{UAS-Wnt2.S} P{UAS-Wnt5.S} P{UAS-Wnt6.S} P{UAS-Wnt10.S} P{UAS-wntD.S}
Genes (19)
	C3G dally dlp dpp dsh Ecol\lacZ en Ext2 hh kn ptc Scer\GAL4 shf ttv Wnt2 Wnt5 Wnt6 Wnt10 wntD
Insertions (7)
	P{CaSpeR}cx34.6 P{CaSpeR}shf^P1 P{en2.4-GAL4}e16E P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}ptc^559.1 P{SUPor-P}KG04261