Reference Report

Reference
Citation	Ayyub, C., Sen, A., Gonsalves, F., Badrinath, K., Bhandari, P., Shashidhara, L.S., Krishna, S., Rodrigues, V. (2005). Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Dev. Dyn. 232(3): 865--875. (Export to RIS)
FlyBase ID	FBrf0183913
Publication Type	Research paper
PubMed ID	15712282
PubMed Abstract	We describe a developmental analysis of Drosophila Cullin-5 (Cul-5) identified from the genome sequence on the basis of its high degree of homology to vertebrate and worm sequences. The gene is expressed in a restricted manner in ectodermal cells throughout development suggesting pleiotropic functions. We decided to examine the phenotypes of Cul-5 aberrations in two well-studied developmental systems: the neuromuscular junction (NMJ) and the developing sensory organ. Alteration of Cul-5 levels in motoneurons results in an increase in bouton number at the NMJ. The cells of a sensory organ on the adult notum arise from a single progenitor cell by regulated cell division. Aberrations in Cul-5 affect different steps in the lineage consistent with a role in cell fate determination, proliferation, and death. Such phenotypes highlight the multiple cellular processes in which Cul-5 can participate.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Dyn.
Title	Developmental Dynamics
Publication Year	1992-
ISBN/ISSN	1058-8388
Data from Reference
Aberrations (1)
	Df(3R)3450
Alleles (16)
	Cul-3⁰⁶⁴³⁰ Cul-5^EP3390 Cul-5^x2 Cul-5^x29 Ecol\lacZ^neur-A101 Scer\GAL4^arm.PS Scer\GAL4^Dll-981 Scer\GAL4^elav.PU Scer\GAL4^GMR.PU Scer\GAL4^hs.PB Scer\GAL4^pros.PMG Scer\GAL4^ptc-559.1 Scer\GAL4^sca-P309 Scer\GAL4^sd-SG29.1 Scer\GAL4^wg.PM wg^{l-12.Scer\UAS}
Constructs (8)
	P{?EP} P{elav-GAL4.U} P{GAL4-arm.S} P{GAL4-Hsp70.PB} P{GAL4-pros.MG} P{GAL4-wg.M} P{GMR-GAL4.U} P{UAS(-FRT)wg.ts}
Genes (15)
	arm ci Csp Cul-3 Cul-5 Dll dpp Ecol\lacZ elav gl ptc sca Scer\GAL4 sd wg
Insertions (7)
	P{?EP}Cul-5^x2 P{EP}Cul-5^EP3390 P{GAL4}Dll⁹⁸¹ P{GAL4}sca^P309 P{GawB}ptc^559.1 P{GawB}sd^SG29.1 P{lArB}neur^A101