Reference Report

Reference
Citation	Taillebourg, E., Moreau-Fauvarque, C., Delaval, K., Dura, J.M. (2005). In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase, a Drosophila Ryk ortholog. Dev. Genes Evol. 215(3): 158--163. (Export to RIS)
FlyBase ID	FBrf0183915
Publication Type	Research paper
PubMed ID	15611849
PubMed Abstract	The RYK subfamily of receptor tyrosine kinases is characterised by unusual, but highly conserved, amino acid substitutions in the kinase domain. The linotte/derailed gene encodes a Drosophila RYK subfamily member involved in embryonic and adult central nervous system development. Previous studies have shown that the kinase activity of this receptor is not required in vivo for its embryonic function. In this study, we have investigated the role of the cytoplasmic domain and the kinase activity of the linotte/derailed receptor tyrosine kinase in adult brain development. Our results indicate that these domains are not essential for adult brain development but they are required for the proper regulation of the activity of this receptor. This sheds light on a regulatory role for the kinase activity of a RYK subfamily member.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Genes Evol.
Title	Development genes and evolution
Publication Year	1996-
ISBN/ISSN	0949-944X
Data from Reference
Alleles (7)
	drl² drl^{K371A.Scer\UAS} drl^R343 drl^Scer\UAS.cCa drl^{Δintra.Scer\UAS.T:Hsap\MYC} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^elav-C155
Constructs (2)
	P{UAS-drl.Δintra.MYC} P{UAS-mCD8::GFP.L}
Genes (5)
	drl Mmus\Cd8a Scer\GAL4 T:Avic\GFP T:Hsap\MYC
Natural transposons (1)
	P-element