Reference Report

Reference
Citation	Kristiansen, L.V., Velasquez, E., Romani, S., Baars, S., Berezin, V., Bock, E., Hortsch, M., Garcia-Alonso, L. (2005). Genetic analysis of an overlapping functional requirement for L1- and NCAM-type proteins during sensory axon guidance in Drosophila. Mol. Cell. Neurosci. 28(1): 141--152. (Export to RIS)
FlyBase ID	FBrf0184161
Publication Type	Research paper
PubMed ID	15607949
PubMed Abstract	L1- and NCAM-type cell adhesion molecules represent distinct protein families that function as specific receptors for different axon guidance cues. However, both L1 and NCAM proteins promote axonal growth by inducing neuronal tyrosine kinase activity and are coexpressed in subsets of axon tracts in arthropods and vertebrates. We have studied the functional requirements for the Drosophila L1- and NCAM-type proteins, Neuroglian (Nrg) and Fasciclin II (FasII), during postembryonic sensory axon guidance. The rescue of the Neuroglian loss-of-function (LOF) phenotype by transgenically expressed L1- and NCAM-type proteins demonstrates a functional interchangeability between these proteins in Drosophila photoreceptor pioneer axons, where both proteins are normally coexpressed. In contrast, the ectopic expression of Fasciclin II in mechanosensory neurons causes a strong enhancement of the axonal misguidance phenotype. Moreover, our findings demonstrate that this functionally redundant specificity to mediate axon guidance has been conserved in their vertebrate homologs, L1-CAM and NCAM.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Neurosci.
Title	Molecular and Cellular Neurosciences
Publication Year	1990-
ISBN/ISSN	1044-7431
Data from Reference
Alleles (19)
	btl::Egfr^{Scer\UAS.T:λ\cI-DD} Ecol\lacZ^neur-A101 Fas1^+3.Scer\UAS Fas2^e76 Fas2^EB112 Fas2^Scer\UAS.cLa Fas2^Scer\UAS.cLb Hsap\L1CAM^{RSLE-.Scer\UAS} Hsap\NCAM1^140.Scer\UAS htl^AB42 Mmus\L1cam^{RSLE+.Scer\UAS} Nrg^167.Scer\UAS Nrg^180.Scer\UAS Nrg^GPI.Scer\UAS Nrg^l3 Rnor\CD2^{Scer\UAS.cDBa} Rnor\Nrcam^Scer\UAS.cKa Scer\GAL4^Bx-MS1096 Scer\GAL4^MS1075
Constructs (12)
	P{UAS-CD2} P{UAS-Egfr.λtop} P{UAS-Fas1.+3} P{UAS-Fas2.PEST-} P{UAS-Fas2.PEST+} P{UAS-hNCAM.140} P{UAS-L1CAM.RSLE-} P{UAS-L1CAM.RSLE+} P{UAS-Nrcam.K} P{UAS-Nrg.180} P{UAS-Nrg.GPI} P{UAS-nrg¹⁶⁷}
Genes (14)
	btl::Egfr Ecol\lacZ Egfr Fas1 Fas2 futsch Hsap\L1CAM Hsap\NCAM1 htl Mmus\L1cam Nrg Rnor\CD2 Rnor\Nrcam Scer\GAL4
Insertions (3)
	P{GAL4}MS1075 P{GawB}Bx^MS1096 P{lArB}neur^A101
Natural transposons (1)
	P-element