Reference Report

Reference
Citation	Gompel, N., Prud'homme, B., Wittkopp, P.J., Kassner, V.A., Carroll, S.B. (2005). Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Nature 433(7025): 481--487. (Export to RIS)
FlyBase ID	FBrf0184175
Publication Type	Research paper
PubMed ID	15690032
PubMed Abstract	The gain, loss or modification of morphological traits is generally associated with changes in gene regulation during development. However, the molecular bases underlying these evolutionary changes have remained elusive. Here we identify one of the molecular mechanisms that contributes to the evolutionary gain of a male-specific wing pigmentation spot in Drosophila biarmipes, a species closely related to Drosophila melanogaster. We show that the evolution of this spot involved modifications of an ancestral cis-regulatory element of the yellow pigmentation gene. This element has gained multiple binding sites for transcription factors that are deeply conserved components of the regulatory landscape controlling wing development, including the selector protein Engrailed. The evolutionary stability of components of regulatory landscapes, which can be co-opted by chance mutations in cis-regulatory elements, might explain the repeated evolution of similar morphological patterns, such as wing pigmentation patterns in flies.
DOI
Related Publication(s)
Review	Evolutionary developmental biology: how and why to spot fly wings. Brakefield and French, 2005, Nature 433(7025): 466--467 [FBrf0184174]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (11)
	Avic\GFP^{Dbii\y.335-530.δ425-453} Avic\GFP^{Dbii\y.335-530} Avic\GFP^Dbii\y.bia5' Avic\GFP^{Dbii\y.leftbia} Avic\GFP^{Dbii\y.leftbialarge} Avic\GFP^{Dbii\y.rightbia} Avic\GFP^Dbii\y.wing Avic\GFP^{Dbii\y.winglarge} Avic\GFP^{Dpse\y.leftbia} Avic\GFP^{Dpse\y.rightbia} Avic\GFP^Dpse\y.wing
Constructs (9)
	P{Dbii\y-GFP.335-530} P{Dbii\y-GFP.bia5'} P{Dbii\y-GFP.wing} P{Dbii\y-GFP.wingleft} P{Dbii\y-GFP.wingleftlarge} P{Dbii\y-GFP.wingright} P{Dpse\y-GFP.wing} P{Dpse\y-GFP.wingleft} P{Dpse\y-GFP.wingright}
Genes (5)
	Avic\GFP Dbii\e Dbii\en Dbii\y Dpse\y
Natural transposons (1)
	P-element
Sequence features (1)
	y_wing