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Citation
King-Jones, K., Thummel, C.S. (2005). Nuclear receptors - a perspective from Drosophila.  Nat. Rev. Genet. 6(4): 311--323.
FlyBase ID
FBrf0184203
Publication Type
Review
Abstract

Nuclear receptors are ancient ligand-regulated transcription factors that control key metabolic and developmental pathways. The fruitfly Drosophila melanogaster has only 18 nuclear-receptor genes - far fewer than any other genetic model organism and representing all 6 subfamilies of vertebrate receptors. These unique attributes establish the fly as an ideal system for studying the regulation and function of nuclear receptors during development. Here, we review recent breakthroughs in our understanding of D. melanogaster nuclear receptors, and interpret these results in light of findings from their evolutionarily conserved vertebrate homologues.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Genet.
    Title
    Nature Reviews. Genetics
    Publication Year
    2000-
    ISBN/ISSN
    1471-0056 1471-0064
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