Reference Report

Reference
Citation	Goldman, A.L., Van der Goes van Naters, W., Lessing, D., Warr, C.G., Carlson, J.R. (2005). Coexpression of two functional odor receptors in one neuron. Neuron 45(5): 661--666. (Export to RIS)
FlyBase ID	FBrf0184216
Publication Type	Research paper
PubMed ID	15748842
PubMed Abstract	One of the most fundamental tenets in the field of olfaction is that each olfactory receptor neuron (ORN) expresses a single odorant receptor. However, the one receptor-one neuron principle is difficult to establish rigorously. Here we construct a receptor-to-neuron map for an entire olfactory organ in Drosophila and find that two receptor genes are coexpressed in one class of ORN. Both receptors are functional in an in vivo expression system, they are only 16% identical in amino acid sequence, and the genes that encode them are unlinked. Most importantly, their coexpression has been conserved for >45 million years. Expression of multiple odor receptors in a cell provides an additional degree of freedom for odor coding.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (2)
	Df(2L)dp-79b Dp(2;2)dpp^d21
Alleles (11)
	acj6⁶ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Or33c^Scer\UAS.cDa Or85e^Scer\UAS.cGa rpr^Scer\UAS.cYa Scer\GAL4^Or22a.8010 Scer\GAL4^Or33c.PG Scer\GAL4^Or42a.PG Scer\GAL4^Or46a.PG Scer\GAL4^Or71a.PG Scer\GAL4^Or85e.PW
Constructs (8)
	P{Or22a-GAL4.8010} P{Or33c-GAL4.G} P{Or42a-GAL4.G} P{Or71a-GAL4.G} P{UAS-mCD8::GFP.L} P{UAS-Or33c.D} P{UAS-Or85e.G} P{UAS-rpr.Y}
Genes (16)
	acj6 brp Dpse\Or33c Dpse\Or85e Mmus\Cd8a Or22a Or22b Or33c Or42a Or46a Or59c Or71a Or85d Or85e rpr Scer\GAL4
Natural transposons (1)
	P-element
Transcripts (6)
	Scer\GAL4^Or22a.8010RA Scer\GAL4^Or33c.PGRA Scer\GAL4^Or42a.PGRA Scer\GAL4^Or46a.PGRA Scer\GAL4^Or71a.PGRA Scer\GAL4^Or85e.PGRA