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Kim, Y.J., Lis, J.T. (2005). Interactions between subunits of Drosophila mediator and activator of proteins.  Trends Biochem. Sci. 30(5): 245--249.
FlyBase ID
FBrf0185677
Publication Type
Review
Abstract
Mediator was first identified because of its activity in activator-stimulated transcription in vivo and in vitro. Later, biochemical fractionation led to the co-purification of the multi-subunit Mediator complex and RNA polymerase II (pol II). Results of these studies suggested a model whereby transcription-activator proteins, which bind to specific gene regulatory sequences, recruit both Mediator and pol II as a holoenzyme in a one-step mechanism. More recent studies of Drosophila Mediator and additional studies in yeast have demonstrated that different transcription activators can bind and recruit Mediator to promoters in vivo in a step that is independent of pol II recruitment. Moreover, the different activators in Drosophila bind and recruit Mediator via physical interactions with specific subsets of proteins. These features of Mediator function seem to be broadly conserved.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Compendium
    Abbreviation
    Trends Biochem. Sci.
    Title
    Trends in Biochemical Sciences
    Publication Year
    1976-
    ISBN/ISSN
    0167-7640 0968-0004
    Data From Reference