Reference Report

Reference
Citation	Lima, S.Q., Miesenbock, G. (2005). Remote control of behavior through genetically targeted photostimulation of neurons. Cell 121(1): 141--152. (Export to RIS)
FlyBase ID	FBrf0187231
Publication Type	Research paper
PubMed ID	15820685
PubMed Abstract	Optically gated ion channels were expressed in circumscribed groups of neurons in the Drosophila CNS so that broad illumination of flies evoked action potentials only in genetically designated target cells. Flies harboring the "phototriggers" in different sets of neurons responded to laser light with behaviors specific to the sites of phototrigger expression. Photostimulation of neurons in the giant fiber system elicited the characteristic escape behaviors of jumping, wing beating, and flight; photostimulation of dopaminergic neurons caused changes in locomotor activity and locomotor patterns. These responses reflected the direct optical activation of central neuronal targets rather than confounding visual input, as they persisted unabated in carriers of a mutation that eliminates phototransduction. Encodable phototriggers provide noninvasive control interfaces for studying the connectivity and dynamics of neural circuits, for assigning behavioral content to neurons and their activity patterns, and, potentially, for restoring information corrupted by injury or disease.
DOI
Related Publication(s)
Review	Remote control of fruit fly behavior. Davis, 2005, Cell 121(1): 6--7 [FBrf0187221] Fly mind control. Anonymous, 2005, Science 308(5720): 350 [FBrf0191498]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (12)
	norpA⁷ Rnor\P2rx2^Act5C.PL Rnor\P2rx2^Scer\UAS.cLa Rnor\Trpv1^Act5C.PL Scer\GAL4^c17 Scer\GAL4^c217 Scer\GAL4^C370 Scer\GAL4^Cha.7.4 Scer\GAL4^elav-C155 Scer\GAL4^nrv2.PS Scer\GAL4^ple.PF Scer\GAL4^{shakB.lethal.4.1}
Constructs (5)
	P{Cha-GAL4.7.4} P{nrv2-GAL4.S} P{ple-GAL4.F} P{shakB(lethal)-GAL4.4.1} P{UAS-Rnor\P2rx2.L}
Genes (4)
	norpA Rnor\P2rx2 Rnor\Trpv1 Scer\GAL4
Insertions (5)
	P{Cha-GAL4.7.4}19B P{GAL4}c17 P{GawB}c217 P{GawB}C370 P{GawB}elav^C155
Natural transposons (1)
	P-element