Reference Report

Reference
Citation	Mikeladze-Dvali, T., Wernet, M.F., Pistillo, D., Mazzoni, E.O., Teleman, A.A., Chen, Y.W., Cohen, S., Desplan, C. (2005). The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell 122(5): 775--787.
FlyBase ID	FBrf0187233
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	16143107
PubMed Abstract	Color vision in Drosophila relies on the comparison between two color-sensitive photoreceptors, R7 and R8. Two types of ommatidia in which R7 and R8 contain different rhodopsins are distributed stochastically in the retina and appear to discriminate short (p-subset) or long wavelengths (y-subset). The choice between p and y fates is made in R7, which then instructs R8 to follow the corresponding fate, thus leading to a tight coupling between rhodopsins expressed in R7 and R8. Here, we show that warts, encoding large tumor suppressor (Lats) and melted encoding a PH-domain protein, play opposite roles in defining the yR 8 or pR8 fates. By interacting antagonistically at the transcriptional level, they form a bistable loop that insures a robust commitment of R8 to a single fate, without allowing ambiguity. This represents an unexpected postmitotic role for genes controlling cell proliferation (warts and its partner hippo and salvador) and cell growth (melted).
Biosis	2005.10313328
Zoological record
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Review	Seeing in color--warts and all. Bateman and McNeill, 2005, Dev. Cell 9(4): 441--442 [FBrf0190192]
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Other Reference Information
Secondary IDs
Language of publication	English
Additional language(s) of abstract
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Place of publication
Published In
Abbreviation	Cell
Title	Cell
Authors
Volume range	1-
Year range	1974-
Page range
Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (2)
	Df(3L)melt-Δ1 Df(3L)melt-Δ3
Alleles (35)
	Ecol\lacZ^{Scer\UAS.T:SV40\nls2} Ecol\lacZ^{int1.melt.T:SV40\nls2} InR³⁵³ InR^ex15 Pi3K92E^A Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} Pi3K92E^{Scer\UAS.T:Hsap\MYC} Pten^Scer\UAS.cGb Pten^dj189 S6k^KQ.Scer\UAS S6k^{STDETE.Scer\UAS} Scer\GAL4^5'.melt Scer\GAL4^GMR.long Scer\GAL4^Rh3.PP Scer\GAL4^Rh4.PT Scer\GAL4^Rh5.PT Scer\GAL4^Rh6.PD Scer\GAL4^int1.melt Scer\GAL4^wts-GAL4 Tsc1^R453X Tsc1^{Scer\UAS.T:Hsap\MYC} corn^Δ1 corn^Δ3 hpo^{318-669.Scer\UAS} hpo^KC203 melt^Bg4-1-2 melt^Scer\UAS.cTa sav^shrp-1 sev¹⁴ wts^GAL4 wts^P1 wts^P509-19 wts^{Scer\UAS.X.T:Hsap\MYC} wts^x1
Constructs (19)
	P{Dp110-CAAX} P{Dp110^D954A} P{GawB} P{Rh3-GAL4} P{Rh4-GAL4} P{Rh5-GAL4} P{Rh6-GAL4.D} P{UAS-Pten.Gb} P{UAS-S6k.KQ} P{UAS-Tsc1.MYC} P{UAS-hpo.K71R} P{UAS-lacZ.NZ} P{UAS-melt.T} P{UAS-wts.X.MYC} P{WT-Dp110} P{longGMR-GAL4} P{melt-GAL4.int1} P{melt-lacZ.int1.nls} P{melt5'-GAL4}
Genes (21)
	Ecol\lacZ InR Pi3K92E Pten Rh3 Rh4 Rh5 Rh6 S6k Scer\GAL4 T:Hsap\MYC T:SV40\nls2 Tsc1 chp corn hpo melt sav sens sev wts
Insertions (3)
	P{GawB}wts^GAL4 P{UAS-lacZ.B}melt^Bg4-1-2 P{lacW}wts^P509-19
Natural transposons (1)
	P-element