Reference Report

Reference
Citation	Gronke, S., Mildner, A., Fellert, S., Tennagels, N., Petry, S., Muller, G., Jackle, H., Kuhnlein, R.P. (2005). Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 1(5): 323--330. (Export to RIS)
FlyBase ID	FBrf0187251
Publication Type	Research paper
PubMed ID	16054079
PubMed Abstract	Energy homeostasis, a fundamental property of all organisms, depends on the ability to control the storage and mobilization of fat, mainly triacylglycerols (TAG), in special organs such as mammalian adipose tissue or the fat body of flies. Malregulation of energy homeostasis underlies the pathogenesis of obesity in mammals including human. We performed a screen to identify nutritionally regulated genes that control energy storage in the model organism Drosophila. The brummer (bmm) gene encodes the lipid storage droplet-associated TAG lipase Brummer, a homolog of human adipocyte triglyceride lipase (ATGL). Food deprivation or chronic bmm overexpression depletes organismal fat stores in vivo, whereas loss of bmm activity causes obesity in flies. Our study identifies a key factor of insect energy homeostasis control. Their evolutionary conservation suggests Brummer/ATGL family members to be implicated in human obesity and establishes a basis for modeling mechanistic and therapeutic aspects of this disease in the fly.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell Metab.
Title	Cell Metabolism
Publication Year	2005-
ISBN/ISSN	1550-4131
Data from Reference
Alleles (16)
	bmm¹ bmm² bmm^EP3174 bmm^{PLD.Scer\UAS.T:Avic\GFP-EGFP} bmm^{PLD-BB.Scer\UAS.T:Avic\GFP-EGFP} bmm^rev bmm^{S38A.Scer\UAS.T:Avic\GFP-EGFP} bmm^{S38A.Scer\UAS} bmm^Scer\UAS.cGa bmm^{Scer\UAS.T:Avic\GFP-EGFP} Lsd-2⁵¹ Lsd-2^Scer\UAS.cGa Scer\GAL4^Act5C.PI Scer\GAL4^fat T:Avic\GFP^EGFP w^+mC
Constructs (9)
	P{3'EP} P{Act5C-GAL4} P{UAS-bmm.cGa} P{UAS-bmm.EGFP} P{UAS-bmm.PLD.EGFP} P{UAS-bmm.PLD-BB.EGFP} P{UAS-bmm.S38A.EGFP} P{UAS-bmm.S38A} P{UAS-Lsd-2.G}
Genes (35)
	alc Amy-d bmm CG4753 CG5966 CG8036 CG11796 dob Elo68α GIIIspla2 Got2 Hex-C hgo Hn Hsl Lk6 LpR2 Lsd-1 Lsd-2 Mal-A5 Mal-A6 Mal-A7 Mal-A8 Mal-B1 Mal-B2 pdgy Pdk Pgm Pka-C3 Scer\GAL4 SNF4Aγ Spat tobi w whd
Insertions (6)
	P{3'EP}bmm¹ P{3'EP}bmm² P{3'EP}bmm^rev P{Act5C-GAL4}25FO1 P{EP}bmm^EP3174 P{GAL4}fat
Natural transposons (1)
	P-element