Open Close
Reference
Citation
Reeve, S.P., Bassetto, L., Genova, G.K., Kleyner, Y., Leyssen, M., Jackson, F.R., Hassan, B.A. (2005). The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain.  Curr. Biol. 15(12): 1156--1163.
FlyBase ID
FBrf0187329
Publication Type
Research paper
Abstract

Loss of Fragile X mental retardation protein (FMRP) function causes the highly prevalent Fragile X syndrome [1 and 2]. Identifying targets for the RNA binding FMRP is a major challenge and an important goal of research into the pathology of the disease. Perturbations in neuronal development and circadian behavior are seen in Drosophila dfmr1 mutants. Here we show that regulation of the actin cytoskeleton is under dFMRP control. dFMRP binds the mRNA of the Drosophila profilin homolog and negatively regulates Profilin protein expression. An increase in Profilin mimics the phenotype of dfmr1 mutants. Conversely, decreasing Profilin levels suppresses dfmr1 phenotypes. These data place a new emphasis on actin misregulation as a major problem in fmr1 mutant neurons.

PubMed ID
PubMed Central ID
Related Publication(s)
Supplementary material
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference
    Aberrations (1)
    Alleles (10)
    Genes (9)
    Physical Interactions (1)
    Insertions (2)
    Transgenic Constructs (4)