Reference Report

Reference
Citation	Kolesnikov, T., Beckendorf, S.K. (2005). NETRIN and SLIT guide salivary gland migration. Dev. Biol. 284(1): 102--111. (Export to RIS)
FlyBase ID	FBrf0187388
Publication Type	Research paper
PubMed ID	15950216
PubMed Abstract	Directed migration is pivotal for the proper placement and function of nearly all organs. The majority of known guidance molecules involved in directed migration have been identified from studies of migrating axons during nervous system development. Here, we show that at least two of these axon guidance molecules, NETRIN and SLIT, act through their canonical receptors, to guide Drosophila embryonic salivary glands. NETRIN serves as a chemo-attractant while SLIT functions antagonistically to NETRIN as a chemo-repellent during salivary gland migration. CNS midline expression of both NETRIN and SLIT directs the glands to move unswervingly parallel to the CNS. NETRIN expression is also required in the visceral mesoderm, along which the glands move during their migration. We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	Df(1)NP5
Alleles (21)
	comm^E39 Ecol\lacZ^Scer\UAS.cBa elav^M454 fra³ fra⁴ fra^Scer\UAS.cKa lea^robo2-1 mew^M6 NetA^{hs.sli.T:Hsap\MYC} NetA^{Scer\UAS.T:Hsap\MYC} NetB^{hs.sli.T:Hsap\MYC} NetB^{Scer\UAS.T:Hsap\MYC} robo¹ Scer\GAL4^bap.3 Scer\GAL4^elav.PLu Scer\GAL4^prd.RG1 Scer\GAL4^sca.PU Scer\GAL4^twi.PB sli² sli^Scer\UAS.cKa unc-5^Scer\UAS.cKa
Constructs (13)
	P{bap-GAL4.3} P{GAL4-elav.L} P{GAL4-prd.F} P{GAL4-twi.B} P{sca-GAL4.U} P{slit-NetA} P{slit-NetB} P{UAS-fra} P{UAS-lacZ.B} P{UAS-NetrinA} P{UAS-NetrinB} P{UAS-sli.K} P{UAS-unc-5.K}
Genes (16)
	comm crb Ecol\lacZ elav Fas3 fkh fra lea mew NetA NetB robo Scer\GAL4 sli T:Hsap\MYC unc-5